不同性别原发性IgA肾病患者的临床与病理特点研究

目的分析不同性别原发性IgA肾病(IgAN)患者的临床、病理特点,了解性别与该病临床、病理特点的关系。方法选择2009年1月至2011年12月梅州市人民医院经肾穿刺活检确诊的原发性IgAN患者158例的临床表现、检测指标及病理分级数据进行统计分析。结果临床特点中,仅水肿在性别上差异有统计学意义(P<0.05);临床指标中,收缩压、舒张压、血尿酸、三酰甘油、白蛋白及补体C3在性别上分析差异均有统计学意义(P<0.05);病理分级中,男性组与女性组比较,差异无统计学意义(P>0.05)。结论性别对IgAN的临床表现及病理分级影响不大,但是临床指标水平在性别上有统计学意义,应加强男性相关指标监测,控制病情。

Study of the Clinical and Pathological Features of Patients with Primary IgA Nephropathy of Different Genders

Objective To analyze the clinical and pathological features of primary IgA nephropathy patients of different genders,find out the relationship between gender and clinical and pathological features of the disease.Methods The clinical manifestations,indicators and pathological classification of 158 IgA nephropathy patients confirmed by renal biopsy were collected for statistical analysis.Results As for the clinical manifestations,there was significant difference in edema between different genders(P<0.05).As for the clinical indexes,there were differences in systolic blood pressure and diastolic blood pressure,uric acid,triglycerides,albumin and complement C3 between different genders(P<0.05).As for the pathological grading,there was no significant difference(P>0.05).Conclusion The clinical manifestations and pathological grading of IgA nephropathy are affected less by the gender,but there are statistically significant difference in the clinical indicators.We should strengthen the monitoring of the related indicators of the male patients to control the disease.