维生素D与免疫功能的研究

维生素D是维持人体生命所必需的营养素,体内的维生素D有内源性和外源性两种,最终被转化为有较强生物活性的1,25-二羟维生素D31,25-(OH)2D3],经血液循环运送到各个靶器官发挥作用。最近研究表明,维生素D是一种新的神经内分泌-免疫调节激素,对细胞免疫具有重要的调节作用,包括维生素D受体(VDR)在免疫相关细胞内的表达,1,25-(OH)2D3对细胞因子生成的调控,VDR和各羟化酶缺损的转基因动物研究等。因此,除了对血钙、血磷代谢的调节预防和治疗佝偻病外,维生素D在免疫功能的调节方面也越来越受关注。

The Research on Vitamin D and Immunity

Viatmin D is an essential nutrient for human life;there are two types of in vivo vitamin D,the endogenous and exogenous,which will eventually be transformed into 1,25-dihydroxyvitamin D31,25-(OH)2D3]of higher bioactivity and transported into different target organs to function.Recent studies have indicated that vitamin D is a new neuroendocrine-immune regulating hormone,playing an important regulatory role in cell immune,including vitamin D receptor(VDR) expression in immune related cells,and 1,25-(OH)2D3] regulation on cytokine generation.Therefore,vitamine D not only can regulate serum calcium and phosphorus metabolism and treat rickets,but also is starting to shine in the immunoregulation.