血浆尾加压素Ⅱ浓度与冠状动脉病变程度的关系

目的：研究血浆尾加压素Ⅱ浓度与冠状动脉病变程度的关系。方法：在100例已知或怀疑冠心病患者中行冠脉造影检查，并用酶联免疫法测量血浆中尾加压素Ⅱ水平。依照冠脉造影结果分为非冠心病组（狭窄〈50％）和冠心病组（狭窄≥50％），病变程度定量采用Micheal评分系统。结果：血浆尾加压素Ⅱ浓度在非冠心病组和冠心病组间无统计学差异（P〉0．05），冠脉正常或极轻微病变组（评分〈3）与冠脉病变严重组（评分〉19）阀有统计学差异（P〈0．05）。血浆尾加压素Ⅱ浓度与冠状动脉病变评分正相关（r=0．213,P〈0．05），与其他危险因素及危险评分不相关。多变量回归分析尾加压素Ⅱ是继年龄、廊糖异常、高血压之后的独立危险因素。结论：在严重冠脉病变患者血浆中尾加压素Ⅱ水平显著升高，并且尾加压素Ⅱ水平与冠脉病变程度明显正相关。

Correlation between serum levels of urotensin Ⅱ and severity of coronary artery disease

Objective：To examine the correlation between urotensin Ⅱ concentration and the severity of coronary artery disease（CAD）.Methods：We studied urotensin Ⅱ concentration in 100 patients with known or suspected CAD referred for cardiac catheterization.Based on coronary angiograms, subjects were classified as having mild or without CAD（stenosis〈50%）and marked CAD（stenosis≥50%）. Micheal score system was used to estimate the severity of CAD.Results：Urotensin Ⅱ concentration in the marked CAD group had no difference compared with mild or without CAD group （1.95±1.18ng/ml vs 2.04±1.47ng/ml,P〉0.05）, but higher in severer group （score≥9） than in normal or nearly normal group （score〈3）,（2.50±1.62ng/ml vs 1.61±1.05ng/ml,P〈0.05）. Urotensin Ⅱ concentration had no relationship with other known risk factors,but it correlated to CAD severity （r=0.213,P〈0.05）.In multiple regression analysis,Urotensin Ⅱ was one determinant of the severity of CAD, other than age, abnornlal glucose,hypertension and gender.Conclusion：Urotensin Ⅱ concentrations are elevated in severe CADs and there is a significant relationship between urotensin Ⅱ concentration and CAD severity.