Effect of voluntary wheel exercise on food intake,water intake,and body weight for C57BL/6J mice and mutations which differ in maximal body weight

The relations of voluntary wheel exercise, food intake, water intake, metabolic rate, and body weight were determined for mutant mice (bg, c^J, A^y, and ob) with C57BL/6J genetic background and also for littermate controls. Mutant groups high in body weight (A^y and ob) had lower metabolic rates, were less active, and ate more food than controls. The nonobese mutants (c^J, and bg) had higher metabolic rates than controls, but different behavioral mechanisms for control of body weight during voluntary wheel exercise. Voluntary wheel activity for the albino (c^J) mice was similar to that of controls, but food intake increased proportionally more for albinos than controls. Food intake was similar for beige (bg) mutants compared with controls, but the beige group engaged in less voluntary wheel activity than controls.