| 乙型病毒性肝炎患者血清可溶性白细胞介素2受体测定的意义 |
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| 引用本文： | 林德馨,高永琳,黄伟明,何艳,叶庆林.乙型病毒性肝炎患者血清可溶性白细胞介素2受体测定的意义[J].临床肝胆病杂志,2003,19(4):222-223. |
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| 作者姓名： | 林德馨 高永琳 黄伟明 何艳 叶庆林 |
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| 作者单位： | 福建医科大学生物化学与分子生物学系,福州,350004 |
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| 基金项目： | 福建省科委资助项目 (批准号 99-Z14 ) |
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| 摘 要： | 检测乙型病毒性肝炎患者血清可溶性白细胞介素2受体(sIL-2R)的水平及其与血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、凝血酶原活动度(PTA)、胆碱酯酶(ChE)及乙肝病毒复制标志物之间的关系。采用酶联免疫法(ELISA)检测77例乙型病毒性肝炎患者和20例正常人血清sIL-2R含量。乙型病毒性肝炎患者血清sIL-2R水平显著高于正常人，并且其升高与ALT、AST、PTA、ChE相关，与乙肝病毒的存在和复制与否无关。急性、慢性、重型乙型病毒性肝炎及乙肝后肝硬化患者血清sIL-2R水平在一定程度上反映了肝细胞损伤及炎症程度。
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| 关 键 词： | 乙型病毒性肝炎 血清可溶性白细胞介素2受体 测定 天冬氨酸氨基转移酶 胆碱酯酶 |
| 文章编号： | 1001-5256(2003)04-0222-02 |
| 修稿时间： | 2002年11月22 |
The significance of serum soluble interleukin 2 receptors in the patients with hepatitis B |
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| LIN De-xin,GAO Yong-lin,HUANG Wei-ming,et al..The significance of serum soluble interleukin 2 receptors in the patients with hepatitis B[J].Chinese Journal of Clinical Hepatology,2003,19(4):222-223. |
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| Authors: | LIN De-xin GAO Yong-lin HUANG Wei-ming |
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| Abstract: | To study the serum level of sIL-2R and the relationships between sIL-2R and liver injury of patients with acute and chronic hepatitis B. The level of sIL-2R was measured by a monoclonal and polyclonal antibody ELISA.The levels of sIL-2R of patients with acute and chronic hepatitis B were significantly higher than those in healthy subjects. The sIL-2R levels in the patients with hepatitis B correlated well with ALT, AST, PTA and ChE. The serum levels of sIL-2R in patients with acute and chronic hepatitis B are increased obviously and reflecting the immune function, degree of liver cells damage and inflammation of the patients. |
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| Keywords: | soluble interleukin 2 receptor(sIL-2R) hepatitis B |
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