Discriminative stimulus properties of arecoline: A new approach for studying central muscarinic receptors |
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Authors: | Leonard T. Meltzer John A. Rosecrans |
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Affiliation: | (1) Department of Pharmacology, Medical College of Virginia, 23298 Richmond, VA, USA;(2) Present address: Neuropsychopharmacology Research Unit, Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, 06710 New Haven, CT, USA |
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Abstract: | Rats were trained to discriminate arecoline (1.74 mg/kg) from saline in a milk-reinforced (variable interval 12 s) two-lever operant paradigm. The discriminative stimulus (DS) effects of arecoline were antagonized by atropine sulfate, but not by atropine methylnitrate or mecamylamine. In contrast to the effects on discrimination, atropine did not antagonize the response rate suppressant effects of arecoline. The DS effect of arecoline completely generalized to oxotremorine, partially generalized to pilocarpine, and did not generalize to nicotine. These data demonstrate that the DS effect of arecoline depends on central muscarinic receptors. |
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Keywords: | Arecoline Drug discrimination Muscarinic receptors |
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