孕中期产妇出生缺陷筛查的临床研究

目的了解486例孕中期产妇3种主要出生缺陷(神经管畸形、21-三体、18-三体)的检出情况。方法采用罗氏全自动发光免疫分析仪,对486例孕中期产妇进行甲胎蛋白(AFP)、绒毛膜促性腺激素(HCG)、游离雌三醇(uE3)的检测。结果所检测孕中期产妇中,21-三体高危儿6例,神经管畸形3例,18-三体0例。占出生缺陷筛查总人数的阳性率为1.85%;其中,年龄35岁及以上孕中期产妇,21-三体高危儿4例,神经管畸形2例,占总筛查人数的阳性率为1.23%,占总阳性率的66.7%。结论孕中期产妇患出生缺陷的风险率较高,对其进行出生缺陷指标的筛查,临床价值较大。

Clinical study on birth defects screening of mid-pregnancy parturients

Objective To understand the detection status of three main birth defects,neural tube malformation,trisomy 21 and trisomy 18,in 486 mid-pregnancy parturients. Methods The Roche fully automatic immunofluorescent analyzer was adopted to detect AFP, HCG and uE3 in 486 mid-pregnancy parturients. Results Among detected mid-pregnancy parturients,trisomy 21 was in 6 cases,neural tube malformation was in 3 cases and trisomy 18 was zero. The positive rate of birth defects accounted for 1.85%of total screening parturients number. Among mid-pregnancy parturients aged ≥35 years old,high risk trisomy 21 was in 4 cases and neural tube malformation was in 2 eases,which accounted for 1.23 % of total screening mid-pregnancy period and 66.7% of total positive rate. Conclusion Mid-pregnancy parturients have the high risk of birth defects. Conducting the birth defects index screening on them has the larger clinical value. mid pregnancy period; birth defects; screening;