细胞间黏附分子-1和P-选择素在鼻息肉中的表达

目的:揭示细胞间黏附分子-1(ICAM-1,CD54)和P-选择素(CD62p)在鼻息肉发病机制中的作用.方法:收集鼻息内标本32例,炎性鼻甲黏膜11例,正常鼻黏膜12例作对照,应用FACScan流式细胞仪测定不同标本内表达这两种黏附分子的阳性细胞数量.结果:鼻息肉和炎性鼻甲黏膜ICAM-1和P-选择素的细胞阳性率均明显高于正常鼻黏膜(P＜0.001);鼻息肉和炎性鼻甲黏膜之间ICAM-1和P-选择素的细胞阳性率差异无显著性(P＞0.05);ICAM-1和P-选择素在鼻息肉中的表达有正相关关系(r=0.900 1,P＜0.001).结论:ICAM-1和P-选择素在鼻炎和鼻息肉发病过程中都起了重要作用,在鼻息肉中二者表达有一致性.

Expressions of intercellular adhesion molecnle-1 and P-selectin on nasal polyps

Objective To reveal the roles of intercellular adhesion molecule- 1 (ICAM- 1, CD54) and P- selectin (CD62p) in the pathogenesis of nasal polyps.Methods The quantity of CD54 and CD62p cells in the specimens (32 nasal polyps, 11 inflammatory turbinate mucosa, and 12 controlled mucosa) were assayed by FACScan flow cytometry. Results There were much more CD54 and CD62p cells in the nasal polyps and inflammatory turbinate mucosa than in the normal mucosa (P< 0.001) while there was little difference between nasal polyps and inflammatory turbinate mucosa (P >0.05). The expression of ICAM- 1 in nasal polyps was positively related to that of P- selectin(r=0.900 1, P< 0.001). Conclusions Both ICAM- 1 and P- selectin play an important role in the pathogenesis of rhinitis and nasal polyps. They are expressed similarly in nasal polyps.