| 烫伤家兔庆大霉素药动学初探 |
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| 引用本文： | 徐美娟,于波涛.烫伤家兔庆大霉素药动学初探[J].中国医院药学杂志,1990,10(11):483-484. |
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| 作者姓名： | 徐美娟 于波涛 |
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| 作者单位： | 海军第四一一医院药研中心，第二军医大学，上海市医药公司质管科，海军第四一一医院药研中心 上海200083，88届毕业生，上海200083 |
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| 摘 要： | 本文通过9只家免烫伤前后静脉注射庆大霉素(3mg/kg)的药动学资料对比发现,20%体表面积烫伤后第4d 的家兔庆大霉素血浓度比烫伤前明显降低;烫伤后药动学参数V_1增加(p<0.05),V_β增加不明显(P>0.05),T_(1/2β)缩短(P<0.05),AUC 减小(P<0.05),结果表明,烫伤使庆大霉素药动学发生改变。
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| 关 键 词： | 庆大霉素 药动学 烫伤家免 |
Preliminary Study on Gentamicin Pharmacokinetics in Scald Burn Rabbits |
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| Yu Mei-juan et al.Preliminary Study on Gentamicin Pharmacokinetics in Scald Burn Rabbits[J].Chinese Journal of Hospital Pharmacy,1990,10(11):483-484. |
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| Authors: | Yu Mei-juan |
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| Abstract: | Tse effect of scald burn on gentamicin pharmacokinetics was studied in 9 ra-bbits.Single intravenous injection of gentamicin(3mg/kg)was given to each ra-bbit before and after scald burn respectively.Gentamicin serum concentration wasmeasured by bioassay.It was found that sentamicin serum level was lower signi-ficantly in rabbits after 20% TBSA scald burn.The pharmacokinetic parametersalso showed that V_1 increased(p<0.05),T1/2 was shorted(P<0.05),AUC decrea-sed(P<0.05).The results suggested that gentamicin pharmacokinetics could bechanged in rabbits after this experimental scald burn. |
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| Keywords: | gentamicin pharmacokinetics scald burn rabbit |
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