| 对氧磷酯酶-1 L/M 55位点基因多态性与缺血性脑卒中关系的研究 |
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| 引用本文： | 卢燕,范学文,杨笑. 对氧磷酯酶-1 L/M 55位点基因多态性与缺血性脑卒中关系的研究[J]. 宁夏医学杂志, 2009, 31(4) |
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| 作者姓名： | 卢燕 范学文 杨笑 |
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| 作者单位： | 宁夏银川市第一人民医院,宁夏,银川,750001;宁夏医科大学附属医院,宁夏,银川,750004 |
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| 基金项目： | 宁夏科技厅科技攻关项目 |
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| 摘 要： | 目的 探讨对氧磷酯酶(PON1)L/M 55基因多态性与缺血性脑卒中 (CAT)的相关性.方法 用聚合酶链式反应-限制性长度片断多态性(PCR-RFLP)技术,对143例CAT患者和122例相匹配的正常对照组PON1 L/M 55基因型及等位基因频率进行检测,并做统计学分析.结果 CAT组与对照组PON1 L/M 55基因多态性的基因型分布分别为LL型85.31%(122/143)、88.52%(108/122);LM型10.49%(15/143)、8.20% (10/122);MM型4.20% (6/143)、3.28% (4/122),CAT 组与对照组组间比较三种基因型差异无统计学意义(P＞0.05).结论 PON1L/M55基因多态性与缺血性脑卒中的发病无关.
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| 关 键 词： | 对氧磷酯酶1 基因多态性 缺血性脑卒中 |
The relationship between paraoxonase-1 L/M55 gene polymorphism and cerebral arterial thrombosis |
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| LU Yan,et al.. The relationship between paraoxonase-1 L/M55 gene polymorphism and cerebral arterial thrombosis[J]. Ningxia Medical Journal, 2009, 31(4) |
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| Authors: | LU Yan et al. |
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| Affiliation: | The First People's Hospital of Yinchuan;Yinchuan 750001;China |
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| Abstract: | Objective To explore the relationship between the PON1 L/M55 gene polymorphism and cerebral arterial thrombosis (CAT).Methods A total of 143 CAT patients and 122 control subjects were enrolled in this study for examination of PON1 L/M55 gene polymorphisms by using polymerise chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results The distribution of the PON1 L/M55 polymorphism between CAT patients and control groups was LL genotype: 85.31% (122/143), 88.52% (108/122); LM genotype: 10.49% ... |
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| Keywords: | Paraoxonase-1 Polymorphism Cerebral arterial thrombosis |
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