| CADASIL患者的中枢前庭功能损害 |
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| 引用本文： | 赵桂萍,唐澍,刘旸,王朝霞,袁云. CADASIL患者的中枢前庭功能损害[J]. 中国神经精神疾病杂志, 2010, 36(2) |
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| 作者姓名： | 赵桂萍 唐澍 刘旸 王朝霞 袁云 |
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| 作者单位： | 1. 北京大学第一医院,北京,100034
2. 北京积水潭医院 |
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| 摘 要： | 目的评价常染色体显性遗传性脑动脉病伴皮质下梗死和白质脑病(cerebral autosomald ominant arteriopathy with subcortical infarcts and leukoencephalopathy,CADASIL)的前庭功能状态。方法CADASIL患者和健康志愿者各17名,进行眼震电图检查,包括凝视性眼震试验、自发性眼震试验、水平扫视试验、水平跟踪试验、水平视动性眼震试验和温度试验,比较两组间结果的差异。结果两组受试者均未发现自发性眼震和凝视性眼震。水平扫视试验中,两组间扫视潜伏期和扫视速度无统计学差异。CADASIL组扫视准确度均低于正常对照组,向左扫视时差异有统计学意义(F=5.751,P0.05)。水平跟踪试验中,CADASIL组跟踪增益值(gain,G)(G左:0.79±0.08,G右:0.76±0.12)小于对照组(G左:0.87±0.04,G右:0.86±0.06),差异有统计学意义(t=-3.739、-2.911,均P0.05)。按照跟踪曲线类型将CADASIL组分为跟踪正常亚组和跟踪异常亚组,发现头晕症状与跟踪运动异常有关(P0.05)。水平视动性眼震试验发现CADASIL组视动性眼震增益值(G左:0.79±0.17,G右:0.78±0.18)小于对照组(G左:0.90±0.08,G右:0.89±0.09),差异有统计学意义(t=-2.342、-2.335,均P0.05)。1例患者进行了温度试验,表现为固视抑制失败。结论CADASIL患者存在中枢前庭功能损害,并且与患者的头晕症状有关。
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| 关 键 词： | 常染色体显性遗传性脑动脉病伴皮质下梗死和白质脑病 眼震电图 前庭功能检查 |
Central vestibular impairment in patients with CADASIL |
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| ZHAO Guiping,TANG Shu,LIU Yang,WANG Zhaoxia,YUAN Yun. Central vestibular impairment in patients with CADASIL[J]. Chinese Journal of Nervous and Mental Diseases, 2010, 36(2) |
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| Authors: | ZHAO Guiping TANG Shu LIU Yang WANG Zhaoxia YUAN Yun |
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| Affiliation: | ZHAO Guiping,TANG Shu,LIU Yang,WANG Zhaoxia,YUAN Yun.Department of Neurology,Peking University First Hospital,Beijing 100034,China |
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| Abstract: | Objective To evaluate the vestibular function in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).Methods Seventeen CADASIL patients were recruited in the present study and 17 healthy volunteers served as control subjects.Electronystagmogram examinations including gaze nystagmus test,spontaneous nystagmus test,saccade test,pursuit test,optokinetic nystagmus test and caloric test were performed in the subjects.Results Neither patients nor cont... |
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| Keywords: | CADASIL Electronystagmography Vestibular function tests |
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