肺炎患者血清超氧化物歧化酶、谷胱甘肽过氧化物酶、总抗氧化能力、丙二醛的测定 |
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引用本文: | 李国富,何一凡,黄木荣,郭洁莲,吴清坛,陈顺金. 肺炎患者血清超氧化物歧化酶、谷胱甘肽过氧化物酶、总抗氧化能力、丙二醛的测定[J]. 南方医科大学学报, 2003, 23(9): 961-962 |
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作者姓名: | 李国富 何一凡 黄木荣 郭洁莲 吴清坛 陈顺金 |
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作者单位: | 1. 湛江中心人民医院检验科,广东,湛江,524037 2. 湛江经济技术开发区综合门诊部,广东,湛江,524005 3. 广东医学院,广东,湛江,524023 4. 石狮市华侨医院,福建,石狮,350000 5. 第一军医大学南方医院检验科,广东,广州,510515 |
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摘 要: | 目的探讨血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、总抗氧化能力(T-AOC)及丙二醛(MDA)的测定在肺炎诊断和治疗中的意义。方法68例肺炎患者按类型分为急性肺炎组、慢性支气管炎合并肺部感染组和急性支气管肺炎组。采用比色法分别测定各组肺炎患者和76例正常人对照组的血清SOD、GSH-Px、T-AOC及MDA浓度。结果3组肺炎患者血清SOD、GSH-Px及MDA的浓度均明显高于正常对照组,而T-AOC则明显低于正常对照组(P<0.05或P<0.01)。另外,各肺炎组间也存在显著性差异(P<0.01)。结论血清SOD、GSH-Px、T-AOC及MDA的测定有助于对肺炎患者的诊断及康复治疗。
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关 键 词: | 肺炎 超氧化物歧化酶 谷胱甘肽过氧化物酶 总抗氧化能力 丙二醛 |
文章编号: | 1000-2588(2003)09-0961-02 |
修稿时间: | 2003-01-03 |
Determination of serum superoxide dismutase, glutathione peroxidase, total antioxidative capacity, malondialdehyde in patients with pneumonia |
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Abstract: | Objective To determine the levels of serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidative capacity (T-AOC) and malondialdehyde (MDA) in patients with pneumonia. Methods Sixty-eight patients with pneumonia were divided into group of acute pneumonia, group of chronic bronchitis complicated by lung infection, and group of bronchopneumonia. The levels of serum SOD, GSH-Px, T-AOC and MDA were detected by colorimetry in the 68 patients and 76 normal control subjects. Results The serum levels of SOD, GSH-Px and MDA were all significantly higher, while T-AOC significantly lower in the 3 patient groups than in the normal subjects. Significant difference in the measurements was also noted between the 3 groups (P<0.01). Conclusion The determination of serum SOD, GSH-Px, T-AOC and MDA may be heepful for the diagnosis and treatment of pneumonia. |
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Keywords: | pneumonia superoxide dismutase glutathione peroxidase totalantioxidation capacity malondialdehyde |
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