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B7-H4联合CA125检测在卵巢癌早期诊断中的研究
引用本文:吴雄君,窦宇红,华建江,徐志康,梁巧玲. B7-H4联合CA125检测在卵巢癌早期诊断中的研究[J]. 湖南中医药大学学报, 2010, 30(8): 17-18. DOI: 10.3969/j.issn.1674-070X.2010.08.005.017.02
作者姓名:吴雄君  窦宇红  华建江  徐志康  梁巧玲
作者单位:广州医学院附属深圳沙井人民医院检验科,广东,深圳,518104
基金项目:深圳市科技计划项目,深圳市宝安区科技计划项目 
摘    要:目的探讨血清标记物B7-H4与血清癌CA125检测在卵巢癌患者早期诊断与预后的临床价值。方法用ELISA夹心法检测49卵巢癌患者治疗前后血清中的B7-H4水平变化,测定患者治疗前后CA125水平的变化,比较B7-H4与CA125水平变化。结果 B7-H4与CA125检测的特异度分别为80%、86.7%,两者联合检测的特异度为96.7%;B7-H4与CA125检测的敏感度依次为83.7%、77.6%,二者联合检测的特异度为95.9%。结论 B7-H4与CA125联合检测可明显提高卵巢癌诊断的特异度与敏感度。

关 键 词:卵巢癌  B7-H4  CA125

Research of the B7-H4 combined with the CA125 in the diagnosis of ovarian cancer
WU Xiong-jun,DOU Yu-hong,HUA Jian-jiang,XU Zhi-kang,LIANG Qiao-ling. Research of the B7-H4 combined with the CA125 in the diagnosis of ovarian cancer[J]. Journal of Traditional Chinese Medicine University of Hunan, 2010, 30(8): 17-18. DOI: 10.3969/j.issn.1674-070X.2010.08.005.017.02
Authors:WU Xiong-jun  DOU Yu-hong  HUA Jian-jiang  XU Zhi-kang  LIANG Qiao-ling
Affiliation:WU Xiong-jun,DOU Yu-hong,HUA Jian-jiang,XU Zhi-kang,LIANG Qiao-ling(Shengzhen Shajing People's Hospital,Guangzhou Medical College,Shenzhen 518104,China)
Abstract:Objective To explore the clinical significance of the newly discovered serum markers B7-H4 and CA125 in the diagnose of ovarian cancer patients.Methods 49 cases were diagnosed with ovarian cancer.And the change of their serum levels of B7-H4 were detected by using sandwich ELISA before and after treatment,and changes of CA125 levels were also detected before and after treatment.Then analysis were made on the changes of B7-H4 level and CA125 level.Results The detection specificity of B7-H4 and CA125 were 80%...
Keywords:B7-H4  CA125
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