| 在体外及体外循环中抑肽酶对ACT的影响 |
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| 引用本文： | 李建华,曾邦雄.在体外及体外循环中抑肽酶对ACT的影响[J].临床麻醉学杂志,1997,13(1):14-16. |
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| 作者姓名： | 李建华 曾邦雄 |
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| 作者单位： | 解放军１６１医院麻醉科，武汉同济医科大学协和医院麻醉科 |
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| 摘 要： | 选择健康献血员及心内直视手术病，观察抑肽酶对全血活化凝血时间的影响。结果：在体外肝素剂量与ＡＣＴ有显著线性相关。抑肽酶单狡应用并不使ＡＣＴ延，但与肝素合用可协同性延长ＡＣＴ值；在体外循环中抑肽酶延长ＡＣＴ的值更为显著，一般超过８００ｓ。结论：抑肽酶可与肝素协同性延长ＡＣＴ，体外循环中应用抑肽酶时应以ＡＣＴ大于８００ｓ作为肝素抗凝标准。
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| 关 键 词： | 体外循环 抑肽酶 肝素 ACT |
Effects of Aprotinin on the Activted Clotting Time in Vitro and during Cardiopulmonary Bypass |
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| Li Jianhua,Sun Jiling,Zeng Bangxing,et al..Effects of Aprotinin on the Activted Clotting Time in Vitro and during Cardiopulmonary Bypass[J].The Journal of Clinical Anesthesiology,1997,13(1):14-16. |
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| Authors: | Li Jianhua Sun Jiling Zeng Bangxing |
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| Institution: | Li Jianhua,Sun Jiling,Zeng Bangxing,et al. Department of Anesthesiology,PLA the 161th Hospital,Wuhan 430010 |
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| Abstract: | e selected healthy volunteers and patients undergoing cardiopulmonary bypass(CPB) to evaluate the effects of aprotinin on the activated clotting time(ACT).Results show that in vitro there was a linear correlation between ACT and plasmic heparin level and using aprotinin alone did not prolong ACT,but aprotinin synergistically enhanced the effects of heparin in a dose dependent fashion.When aprotinin was given during CPB ACT was prolonged furthen and ACT was more than 800 seconds.In conclusions,aprotinin produces synergistic prolongation of ACT with heparin in vitro and during CPB.When aprotinin is used during CPB,ACT should be maintained in a level of more than 800 seconds. |
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| Keywords: | Aprotinin ACT CPB Heparin |
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