EFFECTS OF CAPTOPRIL ON THE SLEEP EEG OF SPONTANEOUSLY HYPERTENSIVE RATS |
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| Authors: | M. K. Sim J. S. Hutchinson M. E. Chua |
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| Affiliation: | Department of Pharmacology, Faculty of Medicine, National University of Singapore, Kent Ridge, Singapore |
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| Abstract: | Intracerebroventricular captopril produces significantly different effects on the sleep electroencephalogram (EEG) of normotensive Wistar-Kyoto (WK) and spontaneously hypertensive rats (SHR). The compound produces a definite pattern of decrease in the percentage and power of the lower frequency EEG of the SHR. Corresponding action on the WK was confined to a general decrease in the power of the EEG. These findings suggest that certain components of the central renin-angiotensin system in the SHR are abnormal. |
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| Keywords: | captopril electroencephalogram hypertensive rats. |
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