| 缺氧诱导因子-1与前列腺癌研究进展 |
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| 引用本文： | 潘周辉,陈昭典. 缺氧诱导因子-1与前列腺癌研究进展[J]. 中华男科学杂志, 2007, 13(4): 356-359 |
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| 作者姓名： | 潘周辉 陈昭典 |
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| 作者单位： | 1. 郑州大学第三附属医院泌尿外科,河南,郑州,450052
2. 浙江大学附属第一医院泌尿外科,浙江,杭州,310003 |
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| 摘 要： | 缺氧诱导因子-1(HIF-1)与前列腺癌存在密切的关系。研究表明HIF-1在前列腺癌中不但与血管生成因子、增殖与存活因子、葡萄糖转运以及糖分解酶等有关,而且与p53、p21、信号转导通路等有关。通过对HIF-1的深入研究将对前列腺癌的诊断与治疗提供新的思路。现对HIF-1的结构、功能及与前列腺癌关系进行综述。
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| 关 键 词： | 前列腺癌 缺氧诱导因子-1 |
| 文章编号： | 1009-3591（2007）04-0356-04 |
| 收稿时间： | 2006-04-28 |
| 修稿时间： | 2006-08-11 |
Hypoxia-inducible Factor 1 and Prostate Cancer |
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| PAN Zhou-hui,CHEN Zhao-dian. Hypoxia-inducible Factor 1 and Prostate Cancer[J]. National journal of andrology, 2007, 13(4): 356-359 |
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| Authors: | PAN Zhou-hui CHEN Zhao-dian |
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| Affiliation: | 1. Department of Urology, the Third Affiliated Hospital, Zhengzhou University, Zhengzhou , Henan 450052 ; 2. Department of Urology, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310003, China |
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| Abstract: | Hypoxia-inducible factor 1 (HIF-1) has a close relation with prostate cancer. It is involved not only in angiogenesis, cell proliferation/survial and glucose metabolism but also in p53, p21 and signal transduction pathway in prostate cancer. Further studies of HIF-1 may yield new approaches to the diagnosis and treatment of prostate cancer. We present a review of the structure and biological functions of HIF-1 and its relation with prostate cancer. |
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| Keywords: | prostate cancer HIF-1 |
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