Expression of DNA methyltransferase in LEC rats during hepatocarcinogenesis |
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| Authors: | Miyoshi, Eiji Jain, Suresh K. Sugiyama, Toshihiro Fujii, Junichi Hayashi, Norio Fusamoto, Hideyuki Kamada, Takenobu Taniguchi, Naoyuki |
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| Affiliation: | 1Department of Biochemistry 2–2 Yamadaoka, Suita, Osaka, 565 Japan
2First Department of Internal Medicine, Osaka University Medical School 2-2 Yamadaoka, Suita, Osaka, 565 Japan |
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| Abstract: | The Long-Evans with a cinnamon-like color (LEC) rat is a mutantof the Long-Evans strain that develops hereditary hepatitisand hepatoma with ageing. Age-related changes in the mRNA expressionof DNA methyltransferase (DNA MTase) were examined in liversof LEC rats using Long Evans with an agouti color (LEA) ratsas controls. A dramatic increase in the expression of this mRNAwas observed in LEC rats at 20 weeks when acute hepatitis appeared.Their high mRNA levels were maintained until 52 weeks of age.The mRNA expression as well as DNA MTase activities were foundto be higher in cancer lesions than in adjacent normal tissue.These increases may be related to liver regeneration and toearly events in cellular transformation of LEC rats. |
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