微血管密度及血管内皮生长因子表达与垂体瘤侵袭性的关系 |
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引用本文: | 潘力雄,刘运生,陈忠平. 微血管密度及血管内皮生长因子表达与垂体瘤侵袭性的关系[J]. 中华神经外科杂志, 2003, 19(4): 285-287 |
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作者姓名: | 潘力雄 刘运生 陈忠平 |
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作者单位: | 1. 广东东莞人民医院,523018 2. 湖南医科大学湘雅医院神经外科 3. 510060,广州,中山医科大学附属肿瘤医院神经外科 |
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摘 要: | 目的探索垂体瘤微循环与侵袭性的关系及其临床意义。方法采用免疫组化技术检测了42例垂体瘤中血管内皮生长因子(VEGF)蛋白表达,同时染色VonWillebrand因子显示血管内皮细胞以检测肿瘤内微血管密度MVD,分析VEGF蛋白表达及MVD与垂体瘤海绵窦侵袭性的关系。结果VEGF蛋白表达和MVD与垂体瘤的海绵窦侵袭性均有关(两者均P<0.001)。结论VEGF与新生血管形成在垂体瘤的侵袭性生物学行为中具有重要的作用。
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关 键 词: | 垂体瘤 微血管密度 血管内皮生长因子 侵袭性 临床意义 免疫组化技术 |
修稿时间: | 2002-05-21 |
Association of vascular endothelial growth factor expression with intratumoral microvessel density and cavernous sinus invasion in pituitary adenomas |
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Abstract: | Objective The aim of this study is to investigate the role of vascular endothelial growth factor(VEGF)expression and intratumoral microvessel density (MVD)in the cavernous sinus in vasive pitutary adenonmas.Methods A total of 42specimens resected from patients with pituitary adenomas were investigated b y using immunohistochemical staining with antibodies against VEGF.At the same time,MVD was assayed by using immuohistochemical staining Von Willebrand facto r in order to highlight microvessel endothelial cells.The expression of VEGF p rotein and MVD were analysed with their relations to the cavernous sinus invasiv e pituitary adenoma.Result Both the expression of VEGF protein and MVD was high ly correlated with the cavernous sinus invasive pituitary adenoma (P<0.01 ).Conclusion VEGF and angiogenesis have potential values for the invasive biol ogical activity in pituitary adenomas. |
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Keywords: | Invasive pituitary adenomas Vascular endothelial growth factor Angiogenesis |
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