微血管密度及血管内皮生长因子表达与垂体瘤侵袭性的关系

目的探索垂体瘤微循环与侵袭性的关系及其临床意义。方法采用免疫组化技术检测了42例垂体瘤中血管内皮生长因子(VEGF)蛋白表达,同时染色VonWillebrand因子显示血管内皮细胞以检测肿瘤内微血管密度MVD,分析VEGF蛋白表达及MVD与垂体瘤海绵窦侵袭性的关系。结果VEGF蛋白表达和MVD与垂体瘤的海绵窦侵袭性均有关(两者均P<0.001)。结论VEGF与新生血管形成在垂体瘤的侵袭性生物学行为中具有重要的作用。

Association of vascular endothelial growth factor expression with intratumoral microvessel density and cavernous sinus invasion in pituitary adenomas

Objective The aim of this study is to investigate the role of vascular endothelial growth factor(VEGF)expression and intratumoral microvessel density (MVD)in the cavernous sinus in vasive pitutary adenonmas.Methods A total of 42specimens resected from patients with pituitary adenomas were investigated b y using immunohistochemical staining with antibodies against VEGF.At the same time,MVD was assayed by using immuohistochemical staining Von Willebrand facto r in order to highlight microvessel endothelial cells.The expression of VEGF p rotein and MVD were analysed with their relations to the cavernous sinus invasiv e pituitary adenoma.Result Both the expression of VEGF protein and MVD was high ly correlated with the cavernous sinus invasive pituitary adenoma (P<0.01 ).Conclusion VEGF and angiogenesis have potential values for the invasive biol ogical activity in pituitary adenomas.