荨麻疹外周血细胞因子表达模式研究进展

荨麻疹的类型多样,发病机制也各不相同.细胞因子在外周血中的水平充分反应疾病的炎症水平及发病机制所牵涉的效应细胞.在急性荨麻疹中,Th2系列因子的高表达证实了急性荨麻疹的过敏性,大量促炎症因子的高表达反映出急性荨麻疹的炎症性.在慢性荨麻疹中,透过外周血细胞因子的表达水平可以发现,不仅Th1/Th2失衡、还有Th17、Tc17和Th9的活化、促炎症因子和趋化因子的广泛激活和非炎症非免疫系统等均参与了慢性荨麻疹的发生发展过程.自体血清皮肤试验不同反应性的慢性荨麻疹的细胞因子表达模式差异也逐渐被证实.除此之外,可诱导性荨麻疹,如寒冷性荨麻疹和延迟压力性荨麻疹等在部分细胞因子表达上也存在差异.

Cytokine expression patterns in peripheral blood of patients with urticaria

Urticaria has various subtypes,and their mechanisms are different from each other.Cytokine levels in peripheral blood fully reflect the degree of inflammation and types of effector cells implicated in the pathogenesis of urticaria.High expressions of T helper type 2 (Th2) cytokines and numerous pro-inflammatory cytokines suggest that acute urticaria is an allergic disease and an inflammatory disease respectively.The expression levels of cytokines in peripheral blood of patients with chronic urticaria hint that Th1/Th2 imbalance,activation of Th17,Tc17 and Th9 cells,massive release of pro-inflammatory factors and chemokines,and noninflammatory and non-immunological systems are all involved in the occurrence and development of chronic urticaria.It has been gradually revealed that cytokine expression patterns differ among chronic urticaria patients with different response to autologous serum skin test.In addition,expressions of some cytokines are also abnormal in patients with inducible urticaria,such as cold urticaria,delayed pressure urticaria,etc.