皮肤病中c-Jun氨基末端蛋白激酶通路的研究现况

c-Jun氨基末端蛋白激酶是丝裂原活化蛋白激酶家族的成员,调节细胞的生长、发育、增殖和分化.c-Jun氨基末端蛋白激酶的异常表达与人皮肤疾病的发生、发展密切相关.研究证实,c-Jun氨基末端蛋白激酶在多种皮肤疾病患者的真/表皮中表达过度增高及异常活化,进而导致细胞的生长、发育、增殖、分化异常以及炎症反应和细胞凋亡的发生.选择阻断c-Jun氨基末端蛋白激酶通路的异常活化可以使病情得到改善.针对c-Jun氨基末端蛋白激酶信号通路的靶向治疗已经成为目前多种皮肤病的研究热点.

c-Jun N-terminal kinase signaling pathway in skin diseases

The c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase (MAPK) family,and can regulate cell growth,development,proliferation and differentiation.Aberrant expression of JNK is closely associated with occurrence and development of human skin diseases.Studies have confirmed that JNK is overexpressed and abnormally activated in the dermis/epidermis of patients with various skin diseases,which can cause abnormalities in cell growth,development,proliferation and differentiation,as well as occurrence of inflammation and apoptosis.Selective blocking of aberrant activation of the JNK signaling pathway may improve patients' condition.At present,therapies targeting the JNK signaling pathway have become a research hotspot in various skin diseases.