| C-erbB-2在乳腺浸润性导管癌中的表达及意义 |
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| 引用本文： | 宋宇豹,牛清华,郑彩虹.C-erbB-2在乳腺浸润性导管癌中的表达及意义[J].临床医药实践,2008,17(3):175-176. |
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| 作者姓名： | 宋宇豹 牛清华 郑彩虹 |
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| 作者单位： | 山西医科大学,山西,太原,030001 |
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| 摘 要： | 目的:探讨C-erbB-2蛋白在乳腺浸润性导管癌中的表达与淋巴结转移的关系。方法:采用免疫组织化学方法(SP法)检测60例乳腺浸润性导管癌组织中C-erbB-2蛋白、雌激素受体(ER)和孕激素受体(PR)的表达,分析其与临床病理指标的关系。结果:60例乳腺癌组织中C-erbB-2蛋白阳性表达占45.00%(27/60),阳性表达率与肿瘤直径、淋巴结转移、组织学分级比较差异有统计学意义,并与ER、PR呈负相关(P<0.05)。结论:C-erbB-2蛋白与乳腺浸润性导管癌侵袭和转移密切相关,可作为判断乳腺癌预后的一个重要指标。
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| 关 键 词： | 乳腺浸润性导管癌 C-erbB-2 淋巴结转移 |
| 文章编号： | 1671-8631(2008)03-0175-02 |
| 修稿时间： | 2007年12月3日 |
Expression of C-erbB-2 in human breast infiltrating ductal carcinoma and its implication |
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| SONG Yu-bao,NIU Qing-hua,ZHENG Cai-hong.Expression of C-erbB-2 in human breast infiltrating ductal carcinoma and its implication[J].Proceeding of Clinical Medicine,2008,17(3):175-176. |
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| Authors: | SONG Yu-bao NIU Qing-hua ZHENG Cai-hong |
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| Abstract: | Objective:To investigate the expression of C-erbB-2 protein in breast infiltrating ductal carcinoma and its role in lymph node metastasis.Methods:Use immunohistochemical method(SP method)to detect the expression of C-erbB-2 protein,Estrogen Recepto and Progesterone Receptor in breast cancer.Results:Twenty ceven cases among 60 cases of breast cancer showed positive expression rate was 45.00%.Positive overexpression of C-erbB-2 was significantly different from tumor size,lymph node metastasis and histological grade of breast cancer and it was in negative correlation with ER and PR.Conclusion:The positive expression of C-erbB-2 plays an important role in human breast infiltrating ductal carcinoma and lylmph node metastasis and can become an important index in judging the prognosis of breast cancer. |
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| Keywords: | breast infiltrating ductal carcinoma C-erbB-2 lymph node metastasis |
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