| 封闭群FMMU白化豚鼠繁殖性能与生长发育的初步观察 |
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| 引用本文： | 王洪涛,袁进,顾为望,李建军,林继红. 封闭群FMMU白化豚鼠繁殖性能与生长发育的初步观察[J]. 实验动物与比较医学, 1997, 17(1): 11-13 |
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| 作者姓名： | 王洪涛 袁进 顾为望 李建军 林继红 |
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| 作者单位： | 湖南中医学院 |
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| 摘 要： | 采用计算系数和病理切片、光镜检查等方法,观察油酸对豚鼠肺的损伤情况。结果表明：油酸组与对照组比较,动物呼吸频率加快,幅度变浅,呈“窘迫状”呼吸困难;肺系数增高（Ｐ〈０．０５）,肺体积明显增大;肺间质充血、出血,肺泡水肿,提示已形成呼吸窘迫综合征模型。山莨菪碱抗油酸所致豚民肺水肿和肺损伤,提示它或有治疗作用
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| 关 键 词： | 呼吸窘迫综合征 豚鼠 动物模型 山莨菪碱 |
Preliminary Observation on Reproductive Performance and Growth of Closed Colony FMMU Albino Guinea pig |
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| Wang Hongtao,et al. Preliminary Observation on Reproductive Performance and Growth of Closed Colony FMMU Albino Guinea pig[J]. Laboratory Animal and Comparative Medicine, 1997, 17(1): 11-13 |
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| Authors: | Wang Hongtao et al |
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| Abstract: | The effects of oleic acid on pulmonary injury in guinea pigs were observed,by the calculation of the pulmonary coefficient and examining the pathological sections. The results indicated that compared with the contrast group, the respiratory rate of the oleic acid group increased,depth of respiration shallowed, showing "distress condition" dyspnea; the pulmonary ceofficient increased (P<0.05),pulmonary volume enlarged obviousely; hyperemia and punctate hemorrhage in pulmonary mesenchyma,edema in pulmonary alveoli. The resuitfs suggest that oleic acid can be used to establish RDS model in guinea pig. Anisodamine can antagonize the pulmonary lesions in guinea pigs caused by oleic acid. |
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| Keywords: | Oleic acid Respiratory Distress Syndrome Guinea pig Anisodamine Lungs |
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