Regulation of T follicular helper cell formation and function by antigen presenting cells |
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Authors: | Deenick Elissa K Ma Cindy S Brink Robert Tangye Stuart G |
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Affiliation: | 1 Immunology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, 2010, NSW, Australia 2 St Vincent''s Clinical School, University of NSW, Kensington, 2033, NSW, Australia |
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Abstract: | CD4+ T cells can differentiate into numerous subsets characterized by expression of a suite of cytokines and effector molecules that endow them with specialized functions. By mediating the differentiation of B cells into memory and plasma cells following exposure to T-dependent antigens (Ag), T follicular helper (TFH) cells have emerged as the predominant subset of CD4+ T cells responsible for regulating humoral immunity. The generation of TFH cells from na?ve precursors typically involves sequential cognate interactions with distinct populations of Ag-presenting cells (APCs): dendritic cells within the T-cell zone of lymphoid tissues, and activated B cells at the border of the T-zone and follicle, and then within a germinal center. Recent studies have illuminated the key roles of APCs in TFH development, and have also re-defined the role of B cells in this process. |
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