清热解毒方对难治性支原体肺炎患儿支原体活体的影响

目的：探讨清热解毒方治疗对难治性支原体肺炎患儿支原体活体的影响。方法：选取本院难治性支原体肺炎住院患儿87例，治疗过程中因故不能坚持退出12例，最终入选75例，随机分为2组。对照组37例，采用阿奇霉素抗菌等治疗。治疗组38例，在阿奇霉素等治疗基础上加用清热解毒方（由生石膏、炙麻黄、桔梗、苦杏仁、连翘、蒲公英、鱼腥草、大青叶、白花蛇舌草等组成）。中药治疗1疗程前后分别采取2组患儿肺泡灌洗液，在超高倍镜下观察肺炎支原体活体变化。结果：治疗后治疗组与对照组患儿肺泡灌洗液支原体活体明显减少，二者比较差异有显著性（P〈0．05）。结论：抑制肺炎支原体活体可能是清热解毒方治疗难治性支原体肺炎的作用机制之一。

Effect of Qingre Jiedu Formula on Living Mycoplasma in Children with Refractory Mycoplasma Pneumonia

Objective： to explore the effect of Qingre Jiedu formula on living mycoplasma in children with refractory mycoplasma pneumonia. Methods： 87 children with efractory mycoplasma pneumonia in the hospital, but finally 75 patients were chosen in the study since 12 patients disengaged for some reasons, among whom 37 patients was control group treated with Azithromycin while the other 38 patients was treatment group treated with Qingre Jiedu formula in addition to Azithromycin. The formula consists of Sheng Shigao （gypsum）, Jiu Mahuang （ Ephedra）, Jiegeng （root of ballconflower）, Ku Xingren （ansu apricot seed）, Lianqiao （weeping forsythia fruit ）, Pugongying （ dandelion ）, Yuxingcao （ heartleaf houttuynia herb ）, Da Qingye （ folium isatidis ） and Bai Hua She She Cao （oldenlandia）, and so on. After one course of treatment with Chinese medicine, patients of both group were given alveolar lavage fluid. The living mycoplasma changes were observed under the ultramicroscope. Results： The living mycoplasma number in treatment group was reduced significantly compared to control group, and the difference was significant （ P 〈 0. 05 ） . Conclusion： Inhibiting the living mycoplasma may be one of the mechanisms of Qingre Jiedu formula in treating refractory mycoplasma pneumonia.