卵巢早衰的病因学研究进展

卵巢早衰（premature ovarian failure，POF）主要是指妇女在40岁以前发生卵巢功能的衰退，其导致的生育力丧失及低雌激素水平已经成为影响夫妇健康生活的两大威胁，近年来更有年轻化的趋势。POF的病因复杂，临床异质性高，主要包括遗传学因素、免疫学因素、医源性因素及代谢、环境、感染等因素。现就此方面进行综述，为进一步了解POF的发生、治疗及预防提供帮助。

Etiology of Premature Ovarian Failure

Premature ovarian failure（POF） is defined as the recession of ovarian function in women under the age of 40 years. The lost fertility and the lowered level of estrogen caused by POF are two factors affected reproductive health and life quality. And the morbidity is tending towards younger women in recent years. The etiological factors and pathogenesis of POF are extremely heterogeneous，involving genetic factors，immune factors，iatrogenic factors，metabolic factors，environmental factors and infection. This review discussed the etiology of POF.