| 淫羊藿苷对家兔阴茎海绵体cGMP浓度的效果 |
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| 引用本文： | 付杰,乔梁,金泰乙,林桂亭,王银叶,辛钟成.淫羊藿苷对家兔阴茎海绵体cGMP浓度的效果[J].中国药理学通报,2002,18(4):430-433. |
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| 作者姓名： | 付杰 乔梁 金泰乙 林桂亭 王银叶 辛钟成 |
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| 作者单位： | 1. 北京大学第一医院泌尿外科、北京大学泌尿外科研究所,北京,100034
2. 北京大学医学部药学院,北京,100086 |
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| 基金项目： | 国家自然科学基金资助项目，No 3 0 0 70 92 7，北京市自然科学基金资助项目，No 70 12 0 2 3，中华医学会专项人才基金资助项目，No文0 47 |
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| 摘 要： | 目的 观察淫羊藿苷对家兔阴茎海绵体组织中cGMP浓度的影响。方法 应用12 5I放射免疫法 ,测定不同浓度的淫羊藿苷对阴茎海绵体内PDE5酶底物cGMP浓度的影响 ,并以西地那非和罂粟碱作为阳性对照。结果 淫羊藿苷能提高阴茎海绵体内cGMP浓度 ,具有浓度依赖性 (P<0 0 0 1) ,其半数有效浓度 (EC50 )为 5 13μmol·L-1,而西地那非 0 31为 μmol·L-1,罂素碱为 3 15 μmol·L-1。结论 淫羊藿苷对阴茎勃起的作用机制与其能提高海绵体平滑肌cGMP浓度而增强阴茎海绵体平滑肌松弛作用有关
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| 关 键 词： | cGMP 阴茎海绵体 淫羊藿苷 勃起 |
| 文章编号： | 1001-1978(2002)04-0430-04 |
Effect of Icarrin on cGMP levels in penile corous cavernosum of rabbit |
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| FU Jie,QIAO Liang,JING Tai Yi,LIN Gui Ting,WANG Yin Ye,XIN Zhong Cheng.Effect of Icarrin on cGMP levels in penile corous cavernosum of rabbit[J].Chinese Pharmacological Bulletin,2002,18(4):430-433. |
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| Authors: | FU Jie QIAO Liang JING Tai Yi LIN Gui Ting WANG Yin Ye XIN Zhong Cheng |
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| Abstract: | AIM To investigate the effect of Icarrin on penile erection and cyclic GMP levels in rabbit corpus cavernosum(RCC). METHODS Effects of various concentration of Icariin on cGMP level in RCC were measured by 125 I radioimmunoassay procedure with Sildenafil and papaverine as the positive controls RESULTS In the presence of SNP, Icariin increased cGMP concentration in rabbit corpus cavernosum in a dose dependent manner ( P <0 01). EC 50 of Icariin was 5 13 μmol·L -1 (while EC 50 of sildenafil and papaverine was: 0 31 μmol·L -1 and 3 15 μmol·L -1 ) respectirely. CONCLUSIONS The effect of Icariin on penile erection may be mediated by increasing cGMP levels in CC for enhancing the relaxation response of CC. |
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| Keywords: | cGMP corpus cavernosum icarrin erection |
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