氟西汀治疗帕金森病伴抑郁的疗效观察

目的:探讨氟西汀治疗帕金森病伴抑郁的临床疗效。方法:将43例帕金森病伴抑郁的患者随机分为氟西汀治疗组23例和对照组20例,基础治疗相同,氟西汀治疗组加用氟西汀20mg/d治疗,于治疗前及治疗8周后采用帕金森病统一评分量表(UPDRS)评定病情严重程度。汉密尔顿抑郁量表(HAMD)17项版本评定抑郁严重程度。结果:氟西汀治疗组在治疗8周后UPDRS及HAMD评分明显减少,抗抑郁疗效总有效率明显高于常规药物治疗组。结论:氟西汀治疗PD伴抑郁患者,不但能有效改善抑郁状态,同时也有利于改善运动障碍,对患者生活质量的改善有积极作用。

The Clinic Observation to Fluoxetine though Treating Parkinson's with Depression

Objective:To explore the clinical effect of fluoxetine in the patients with Parkinson's disease(PD)and depression.Methods:43 cases of PD with depression were randomly divided into therapy group(23 cases) and control group(20cases),On the same basic treatment,the therapy group was treated with fluoxetine(20 mg/d) additionally.Disease severity was evaluated by the unified Parkinson's disease rating scale(UPDRS) and the level of depression was evaluated by 17-item Hamilton-Depression Rating Scale(HAMD-17) before and after 8 weeks treatment.Results:At the end of 8th week,the scores of UPDRS and HAMD in the therapy group were significantly reduced,and the total effective antidepressant efficacy was significantly higher than that of control group.Conclusion:Fluoxetine in the treatment of PD patients with depression,can not only effectively improve the depressive state,but restore movement disorders obviously.Fluoxetine plays a positive role in improving the patient's life quality.