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| 淀粉微球对乳酸环丙沙星的载药特性和吸附机理研究 | |
| 引用本文： | 聂松柳,裘兰兰,马小涛,王柏,何华.淀粉微球对乳酸环丙沙星的载药特性和吸附机理研究[J].海峡药学,2010,22(5):32-35. |
| 作者姓名： | 聂松柳 裘兰兰 马小涛 王柏 何华 |
| 作者单位： | 1. 安徽省六安市人民医院药剂科,六安,237005 2. 中国药科大学分析化学教研室,南京,210009 3. 中国药科大学药剂教研室,南京,210009 4. 中国药科大学分析化学教研室,南京210009;药物质量与安全预警教育部重点实验室,南京210009 |
| 摘 要： | 目的研究淀粉微球对乳酸环丙沙星的载药性能和吸附机理。方法采用反相乳液聚合法制备空白淀粉微球,以乳酸环丙沙星作为模型药物,吸附载药法考察淀粉微球的载药性能,紫外可见分光光度法测定其载药量及包封率,并考察吸附时间、投药量对载药量的影响,同时对淀粉微球的吸附机理进行了探索,测定了热力学参数。结果反相乳液聚合法制备的空白淀粉微球对乳酸环丙沙星的载药量大于100mg·g^-1,包封率可达60%,吸附等温式符合Freundlich公式,可描述为Q=20.36Ce1.73,吸附过程中焓变等于-18.82 kJ·moL^-1,熵变等于-22.65J/mol·K^-1,结论淀粉微球可作为乳酸环丙沙星的载体,对乳酸环丙沙星的吸附机理以物理吸附为主。 |
| 关 键 词： | 淀粉微球 乳酸环丙沙星 吸附载药法 紫外分光光度法 吸附机理 |
Studies on the drug-loading Property and adsorption mechanism of starch microsphere for ciprofloxacin |
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| NIE Song-liu,QIU Lan-lan,MA Xiao-tao,WANG Bo,HE Hua.Studies on the drug-loading Property and adsorption mechanism of starch microsphere for ciprofloxacin[J].Strait Pharmaceutical Journal,2010,22(5):32-35. | |
| Authors: | NIE Song-liu QIU Lan-lan MA Xiao-tao WANG Bo HE Hua |
| Institution: | 1.Department of Pharmacy;The Luan People s Hospital of Bengbu;Luan 237005,China;2.Department of Analytical Chemistry,China Pharmaceutical University; Nanjing 210009,China;3.Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China;4.Key Laboratory of Drug Quality Control and Pharmacovigilance;Ministry of Education,Nanjing 210009,China) |
| Abstract: | OBJECTIVE Studies on the Drug-loading Property and Adsorption Mechanism of Starch Microsphere for ciprofloxacin.METHODS The starch-based microsphere that was crosslinked with epichlorohydrion using a water-in-oil emulsification was prepared.The ciprofloxacin-loaded starch microsphere was made by adsorption method.The drug-loading rate and embedding capacity are mesured by UV spectrum,then the effect of drug quantity,adsorption time,temperature on the drug-loading rate and the adsorption mechanism were investigated.The thermodynamic parameters of starch microsphere adsorpting ciprofloxacin was determined.RESULTS The results show adsorption quantity is more than 100mg·g^-1 while entrapment rate is above 60%,the adsorption isotherm can be described as Q=20.36Ce1.73,the enthalpy change is-18.82 kJ·mol^-1,the entropy change is-22.65 J/mol·K^-1.CONCLUSION The Starch Microsphere can be used as carrier of ciprofloxacin,the main adsorption methanism for ciprofloxacin is the physical adsorption. |
| Keywords: | starch microsphere ciprofloxacin adsorption UV spectrum adsorption mechanism |
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