ACE基因I/D多态性与重度子(癎)前期肾脏损害的关系

目的：探讨血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性与重度子前期肾脏损害的关系,以揭示子前期肾脏损害的分子生物学机制。方法：将63例重度子癎前期患者按有无肾损害分为两组。应用聚合酶链反应（PCR）技术检测两组患者与40例正常孕妇的ACE基因I/D多态性分布。结果：重度子前期组与正常孕妇组比较,基因型分布和等位基因频率差异均无统计学意义（均P〉0.05）;重度子癎前期肾损害组DD基因型频率及D等位基因频率显著高于无肾损害组及对照组（均P〈0.05）。结论：ACE基因I/D多态性与重度子癎前期发病无密切相关;ACE基因DD型可能是重度子癎前期肾脏损害的独立危险因素。

Relationship between Angiotensin Converting Enzyme Gene Polymorphism and Renal Lesions in Severe Preeclampsia

Objective: To investigate the relationship between the insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) gene and renal lesions in severe preeclampsia (S-PE), and explore the molecular mechanism of the kidney lesion in S-PE. Methods: The ACE genotyping with polymorase chain reaction (PCR) was performed in 63 patients with S-PE and 40 healthy pregnant women. Results: The frequencies of deletion/deletion (DD) genotype and deletion allele showed no significant differences between patients with S-PE and healthy pregnant women(P > 0.05). The frequencies of DD genotype and deletion allele among S-PE complicated with kidney lesion were higher than those of S-PE without kidney lesion and healthy pregnant women(P < 0.05). Conclusion: There was no significant relationship between I/D polymorphism of ACE gene and S-PE. The genotype DD of ACE gene may be an independent risk factor for renal lesions in S-PE.