Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice |
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| Authors: | Bettina H Clausen Kate L Lambertsen Alicia A Babcock Thomas H Holm Frederik Dagnaes-Hansen Bente Finsen |
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| Affiliation: | (1) Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark;(2) Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark |
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| Abstract: | Background Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are expressed by microglia and infiltrating macrophages following ischemic stroke. Whereas IL-1β is primarily neurotoxic in ischemic stroke, TNF-α may have neurotoxic and/or neuroprotective effects. We investigated whether IL-1β and TNF-α are synthesized by overlapping or segregated populations of cells after ischemic stroke in mice. |
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