| Hedgehog-Gli信号通路失调控对肝细胞癌生长和转移潜能的影响及其靶向治疗 |
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| 引用本文： | 黄修燕,黄自丽,郑起.Hedgehog-Gli信号通路失调控对肝细胞癌生长和转移潜能的影响及其靶向治疗[J].中华肿瘤防治杂志,2010,17(6). |
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| 作者姓名： | 黄修燕 黄自丽 郑起 |
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| 作者单位： | 1. 上海交通大学附属第六人民医院普外科,上海,200233
2. 上海交通大学附属第六人民医院普外科,上海,200233;皖南医学院附属弋矶山医院神经内科,安徽,芜湖,241001 |
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| 基金项目： | 国家重点基础研究(973)项目(2004CB518708); 上海交通大学附属第六人民医院课题(医院-1131) |
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| 摘 要： | 目的:了解Hedgehog(Hh)-Gli信号通路失调控在肝细胞癌(HCC)发生、发展中的作用及其分子靶向治疗的研究现状。方法:以Hedge-hog、肝癌/hepatocellular carcinoma(HCC)为关键词,使用CNKI(1994-2009)、NCBI(1974-2009)生物信息学数据库对已发表的文章进行检索,共检索到英文27篇,中文7篇,排除重复研究和与本研究无关的文献,最终纳入分析27篇文章。结果:研究发现,Hh信号通路不仅调控胚胎时期各胚层组织发育,而且与肿瘤发生、发展密切相关。Gli作为脊椎动物Hh信号通路锌指核转录因子,与Hh通路下游基因的特定序列结合,直接调控Hh信号通路目的基因的转录表达,在Hh信号通路调控中起到枢纽作用。Hh-Gli信号转导通路的异常激活参与HCC的发生及恶性生物学特性的维持。环杷明和(或)Gli-si RNA可以阻断Hh信号通路抑制HCC生长、侵袭和运动潜能。结论:Hh通路的激活是HCC侵袭、发展的重要因素,阻断Hh通路可能是一种新的潜在的HCC靶向治疗策略,具有临床应用价值。
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| 关 键 词： | 癌 肝细胞 信号通路 转录因子 综述文献 |
Effects of dysregulation in Hedgehog-Gli singnaling pathway on growth and metastatic potential of human hepatocellular carcinoma,and its advances of molecular targeted therapy |
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| HUANG Xiu-yan,HUANG Zi-li,ZHENG Qi.Effects of dysregulation in Hedgehog-Gli singnaling pathway on growth and metastatic potential of human hepatocellular carcinoma,and its advances of molecular targeted therapy[J].Chinese Journal of Cancer Prevention and Treatment,2010,17(6). |
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| Authors: | HUANG Xiu-yan HUANG Zi-li ZHENG Qi |
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| Institution: | HUANG+Xiu-yan1,HUANG+Zi-li1,2,ZHENG+Qi1+1.Department+of+General+Surgery,Sixth+People%5c's+Hospital+Affiliated+to+Shanghai+Jiaotong+University,Shanghai+200233,P.R.China2.Department+of+Neurology,Yijishan+Hospital,Wannan+Medical+College,Wuhu+241001,P.R.China |
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| Abstract: | OBJECTIVE: To understand the effects of the dysregulation in Hedgehog(Hh)-Gli singnaling pathway on the development of hepatocellular carcinoma(HCC),and its advances of molecular therapeutic strategies targeted on Hh-Gli pathway.METHODS: With the keywords of Hedgehog and hepatocellular carcinoma(HCC),we applied CNKI(1994-2009) and NCBI(1974-2009) bioinformatics databases to search published articles.Totally 27 English articles and 7 Chinese articles were collected.The articles that were repetitive studies a... |
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