| 常见药物毒性相关的肠道菌群研究进展 |
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| 引用本文： | 杜伟,陈慧,黄思行,黄崇刚,张莉.常见药物毒性相关的肠道菌群研究进展[J].中国现代应用药学,2022,39(24):3322-3325. |
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| 作者姓名： | 杜伟 陈慧 黄思行 黄崇刚 张莉 |
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| 作者单位： | 重庆市中药研究院,重庆市中药研究院,重庆市中药研究院,重庆市中药研究院,重庆市中药研究院 |
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| 基金项目： | 重庆市科技局技术创新与应用发展项目(cstc2020jscx-lyggX0004)；重庆市中药研究院基本科研项目(jbky20200014) |
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| 摘 要： | 肠道菌群在物质信息传递、代谢等方面发挥重要作用，随着生物技术的进步，人们对肠道菌群与宿主健康的关系有了进一步的认识。近年来的研究发现，肠道菌群与某些药物毒性存在相关性。文章总结了药物肝毒性、肾毒性、神经毒性和生殖及幼龄毒性相关的肠道菌群研究成果，以期为药物毒理研究提供参考。
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| 关 键 词： | 肠道菌群 药物 毒性 |
| 收稿时间： | 2021/8/19 0:00:00 |
| 修稿时间： | 2022/7/31 0:00:00 |
Research Progress of Gut Microflora Related to Common Drug Toxicity |
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| DU Wei,CHEN Hui,HUANG Sixing,HUANG Chonggang,ZHANG Li.Research Progress of Gut Microflora Related to Common Drug Toxicity[J].The Chinese Journal of Modern Applied Pharmacy,2022,39(24):3322-3325. |
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| Authors: | DU Wei CHEN Hui HUANG Sixing HUANG Chonggang ZHANG Li |
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| Institution: | Chongqing Academy of Traditional Chinese Medicine,Chongqing Academy of Traditional Chinese Medicine,Chongqing Academy of Traditional Chinese Medicine,Chongqing Academy of Traditional Chinese Medicine,Chongqing Academy of Traditional Chinese Medicine |
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| Abstract: | Gut microflora plays an important role in material information transmission and metabolism. With the progress of biotechnology, researchers have a further understanding of the relationship between gut microflora and host health. Recent studies have found that there is a correlation between gut microflora and the toxicity of some drug. This paper reviews the research on gut microflora related to drug hepatotoxicity, nephrotoxicity, neurotoxicity, reproductive and juvenile toxicity, in order to provide reference for drug toxicology research. |
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| Keywords: | Gut microflora drug toxicity |
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