Development of a gene transfer-based treatment for radiation-induced salivary hypofunction |
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| Authors: | Bruce J Baum Changyu Zheng Ilias Alevizos Ana P Cotrim Shuying Liu Linda McCullagh Corinne M Goldsmith Nancy McDermott John A Chiorini Nikolay P Nikolov Gabor G Illei |
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| Institution: | 1. Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA;2. Clinical Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA;1. Départment de radiothérapie, institut Claudius-Regaud, institut universitaire du cancer de Toulouse – Oncopole, 1, avenue Irène-Joliot-Curie, 31100 Toulouse, France;2. Institut de recherche biomédicale des armées, BP73, 91223 Brétigny-sur-Orge cedex, France;3. Département de radiothérapie, institut de cancérologie de la Loire Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France;4. Laboratoire de radiobiologie cellulaire et moléculaire, UMR 5822, institut de physique nucléaire de Lyon (IPNL), 69622 Villeurbanne, France;5. UMR 5822, CNRS, domaine scientifique de la Doua, 4, rue Enrico-Fermi, 69622 Villeurbanne cedex, France;6. UMR 5822, université Lyon 1, domaine scientifique de la Doua, 4, rue Enrico-Fermi, 69622 Villeurbanne cedex, France;7. UMR 5822, université de Lyon, domaine scientifique de la Doua, 4, rue Enrico-Fermi, 69622 Villeurbanne cedex, France;8. Service de santé des armées, école du Val-de-Grâce, 74, boulevard de Port-Royal, 75005 Paris, France;9. Département de radiothérapie, Gustave-Roussy Cancer Campus, 114, rue Édouard-Vailant, 94805 Villejuif, France;1. Institute of Pharmaceutical Science, King’s College London, 150 Stamford Street, London SE1 9NH, UK;2. Reckitt Benckiser Health Care, Danson Lane, Hull HU8 7DS, UK;3. Institute of Mucosal & Salivary biology, King’s College London, Thomas Street, London SE1 9RT, UK;1. Stomatology Department, A.C. Camargo Cancer Center, São Paulo, Brazil;2. Nuclear Medicine Department, A.C. Camargo Cancer Center, São Paulo, Brazil;3. Head and Neck Department, A.C. Camargo Cancer Center, São Paulo, Brazil;4. Radiotherapy Department, A.C. Camargo Cancer Center, São Paulo, Brazil;5. Head and Neck Department, Hospital do Câncer de Barretos, São Paulo, Brazil;1. Department of Oncology, Odense University Hospital, Denmark;2. Department of Clinical Research, University of Southern Denmark, Odense C, Denmark;3. OPEN, Odense Patient Data Explorative Network, Department of Clinical Research, University of Southern Denmark, Odense C, Denmark;4. Fertin Pharma A/S, Vejle, Denmark;5. Laboratory of Radiation Physics, Odense University Hospital, Denmark;6. Experimental Clinical Oncology, Department of Oncology, Aarhus University Hospital, Denmark |
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| Abstract: | A significant long-term side effect of radiation therapy for head and neck cancers is xerostomia, a dry mouth, due to salivary gland damage. Despite continuing efforts to eliminate this problem, many patients continue to suffer. This brief review describes our efforts to develop a gene transfer approach, employing the aquaporin-1 cDNA, to treat patients with existing radiation-induced salivary hypofunction. A Phase I/II clinical trial, using a recombinant adenoviral vector to mediate gene transfer, is currently underway. |
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