|
|||||
|
|
Sleep,brain vascular health and ageing |
|
| Authors: | Mahalakshmi Arehally M. Ray Bipul Tuladhar Sunanda Bhat Abid Bishir Muhammed Bolla Srinivasa Rao Yang Jian Essa Musthafa Mohamed Chidambaram Saravana Babu Guillemin Gilles J. Sakharkar Meena Kishore |
| Affiliation: | 1.Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, 570015, India ;2.Centre for Experimental Pharmacology and Toxicology, Central Animal Facility, JSS Academy of Higher Education & Research, Mysuru, Karnataka, 570015, India ;3.Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Nur-Sultan City, Kazakhstan ;4.Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, 107 Wiggins Road, Saskatoon, SK, S7N 5E5, Canada ;5.Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman ;6.Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia ;7.College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, S7N 5A2, Canada ; |
| Abstract: | Sleep maintains the function of the entire body through homeostasis. Chronic sleep deprivation (CSD) is a prime health concern in the modern world. Previous reports have shown that CSD has profound negative effects on brain vasculature at both the cellular and molecular levels, and that this is a major cause of cognitive dysfunction and early vascular ageing. However, correlations among sleep deprivation (SD), brain vascular changes and ageing have barely been looked into. This review attempts to correlate the alterations in the levels of major neurotransmitters (acetylcholine, adrenaline, GABA and glutamate) and signalling molecules (Sirt1, PGC1α, FOXO, P66shc, PARP1) in SD and changes in brain vasculature, cognitive dysfunction and early ageing. It also aims to connect SD-induced loss in the number of dendritic spines and their effects on alterations in synaptic plasticity, cognitive disabilities and early vascular ageing based on data available in scientific literature. To the best of our knowledge, this is the first article providing a pathophysiological basis to link SD to brain vascular ageing. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |