中国肝细胞癌和肝内胆管细胞癌临床诊疗情况比较研究

目的 分析中国多中心肝细胞癌(hepatocellular carcinoma,HCC)和肝内胆管细胞癌(intrahepatic cholangio-carcinoma,ICC)的临床诊疗情况,为制定肝癌防治措施提供依据.方法 研究对象来源于2016—2017年全国12个省市33家医院首次确诊/治疗的新发HCC和IC...

A comparative study on clinical diagnosis and treatment of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in China

ObjectiveTo analyze the clinical diagnosis and treatment of hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC)from various clinical centers in China,and to provide the evidence for prevention and treatment measures.MethodsThe studied objects were gathered from new HCC or ICC cases diagnosed/treated for the first time in 33 hospitals in 12 provinces and cities from 2016 to 2017.The basic information,risk factors,clinical diagnosis and treatment information were collected,and the distribution characteristics of HCC and ICC were compared.ResultsA total of 3,258 liver cancer patients HCC were collected,including 2,671 males(81.98%)and 587 females(18.02%),with 2,928 HCC patients(89.87%)and 330 ICC patients(10.13%).In both HCC and ICC patients,the proportion of males were higher than that of females,and the urban patients were more than the rural patients.The mean onset ages of HCC and ICC were(56.44±11.65)and(61.20±10.92)years,respectively.In HCC patients,the proportions of patients with smoking history(43.64%vs 33.44%,P=0.0004),with alcohol drinking history(31.14%vs 22.15%,P=0.0008),with a history of liver related disease(67.74%vs 34.16%,P<0.0001)and hepatitis B virus carriers(79.37%vs 64.55%,P=0.0002)were all higher than those in ICC patients.The proportions of HCC patients at early stage(Ⅰ-Ⅱstage)and advanced stage(Ⅲ-Ⅳstage)were 44.10%and 55.90%,respectively,while those of ICC patients were 17.01%and 82.99%,respectively,with statistically significant differences(P<0.0001).The main treatment options for HCC and ICC patients were surgery,interventional therapy and chemotherapy,the ratios of surgery were 60.64%and 45.31%,respectively;the ratios of interventional treatment were 23.86%and 21.50%,respectively;the ratios of chemotherapy were 22.13%and 24.77%,respectively.Conclusions The distribution characteristics of the HCC and ICC patients in China are different,and the proportion of advanced stage at the first diagnosis is high,and the main treatment options are surgery,interventional treatment and chemotherapy.HCC is the most common type of liver cancer,the prevention and control of liver cancer should be focused on male,middle-aged and elderly people.