结直肠癌组织HHLA2、 TMIGD2表达及其临床病理意义

目的 探讨结直肠癌组织中人内源性逆转录病毒-H长末端重复关联蛋白2(HHLA2)、跨膜和免疫球蛋白结构域2(TMIGD2)表达及其与患者临床病理特征及预后的关系.方法 选取2016年10月至2017年10月于北京老年医院住院治疗的168例结直肠癌患者(结直肠癌组);选取结直肠癌患者相应癌旁正常组织作为对照组.采用免疫组...

Expression and clinicopathological significance of HHLA2 and TMIGD2 in colorectal cancer tissues

Objective To investigate the relationship between the expression of human endogenous retrovirus-H long terminal repeat-associating protein 2(HHLA2),transmembrane and immunoglobulin domain containing 2(TMIGD2)in colorectal cancer tissues and their clinicopathological features,prognosis.Methods From Oct.2016 to Oct.2017,the colorectal cancer tissues of 168 patients in Beijing Geriatric Hospital were taken as colorectal cancer group;and the adjacent normal tissues of colorectal cancer patients were selected as control group.The expression levels of HHLA2 and TMIGD2 were detected by immunohistochemistry,and the patients were divided into HHLA2 positive group,HHLA2 negative group,TMIGD2 positive group and TMIGD2 negative group;Chi square test was used to analyze the relationship between the expression levels of HHLA2 and TMIGD2 and clinicopathological features.Kaplan-Meier method was used to analyze the relationship between the expression of HHLA2 and TMIGD2 and the prognosis of colorectal cancer patients;multivariate Cox regression analysis was used to analyze the prognostic factors of colorectal cancer.Results The positive expression rates of HHLA2 and TMIGD2 in colorectal cancer group were higher than those in control group(P<0.05).There were significant differences in tumor diameter,tumor invasion,lymph node metastasis,Duke stage and tumor differentiation between HHLA2,TMIGD2 positive expression groups and negative expression groups(P<0.05).The 3-year survival rate of colorectal cancer patients with HHLA2 negative expression(84.48%)was higher than that of patients with HHLA2 positive expression(61.82%)(χ²=9.227,P<0.05);the 3-year survival rate of patients with TMIGD2 negative expression(80.56%)was higher than that of patients with TMIGD2 positive expression(61.46%)(χ²=7.097,P<0.05).HHLA2,TMIGD2 and Duke stage were independent risk factors of colorectal cancer death(P<0.05).Conclusion The high expression of HHLA2 and TMIGD2 is correlated with tumor diameter,tumor invasion,lymph node metastasis,Duke stage,tumor differentiation and prognosis in patients with colorectal cancer,which may become molecular markers for predicting long-term prognosis.