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SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice |
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| Authors: | Soares Rogerio N Ramirez-Perez Francisco I Cabral-Amador Francisco J Morales-Quinones Mariana Foote Christopher A Ghiarone Thaysa Sharma Neekun Power Gavin Smith James A Rector R Scott Martinez-Lemus Luis A Padilla Jaume Manrique-Acevedo Camila |
| Institution: | 1.Department of Medicine, University of Missouri, Columbia, MO, USA ;2.Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA ;3.Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA ;4.Research Service, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO, USA ;5.Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, MO, USA ;6.Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA ;7.Department of Biomedical, Biological and Chemical Engineering, University of Missouri, Columbia, MO, USA ;8.Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Missouri, Columbia, MO, USA ; |
| Abstract: | GeroScience - Aging of the vasculature is characterized by endothelial dysfunction and arterial stiffening, two key events in the pathogenesis of cardiovascular disease (CVD). Treatment with sodium... |
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