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Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice |
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| Authors: | Farias Quipildor Gabriela E. Mao Kai Hu Zunju Novaj Ardijana Cui Min-Hui Gulinello Maria Branch Craig A. Gubbi Sriram Patel Khushbu Moellering Douglas R. Tarantini Stefano Kiss Tamas Yabluchanskiy Andriy Ungvari Zoltan Sonntag William E. Huffman Derek M. |
| Affiliation: | 1.Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer Bldg, Rm 236, 1300 Morris Park Avenue, Bronx, NY, 10461, USA ;2.Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA ;3.Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, USA ;4.Behavioral Core Facility, Dominick S. Purpura Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA ;5.Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA ;6.Department of Internal Medicine, Jacobi Medical Center, Bronx, NY, USA ;7.Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA ;8.Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA ; |
| Abstract: | GeroScience - Disruptions in growth hormone/insulin-like growth factor-1 (GH/IGF-1) signaling have been linked to improved longevity in mice and humans. Nevertheless, while IGF-1 levels are... |
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