| 高效液相色谱法同时测定胆汁、胰液中的加替沙星、左氧氟沙星和奥硝唑 |
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| 引用本文： | 任志强,张毕奎,童启文,刘丽君.高效液相色谱法同时测定胆汁、胰液中的加替沙星、左氧氟沙星和奥硝唑[J].中国药学杂志,2006,41(6):445-447. |
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| 作者姓名： | 任志强 张毕奎 童启文 刘丽君 |
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| 作者单位： | 1. 益阳市中心医院药剂科,湖南,益阳,413000
2. 中南大学湘雅二医院临床药学研究室,长沙410011 |
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| 摘 要： | 目的建立RP-HPLC测定胆汁与胰液中加替沙星、左氧氟沙星和奥硝唑浓度的方法。方法以乙腈-0.3%磷酸(16∶84,三乙胺调pH为2.5)为流动相,流速为1.0 mL·min-1,检测波长286 nm。结果加替沙星、左氧氟沙星、奥硝唑质量浓度分别在0.064～4.80,0.064～4.80,0.16～12.80 mg·L-1内线性关系良好,有较好的回收率与精密度。结论本法适用于对胆汁与胰液中该3种药物的监测。
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| 关 键 词： | 反相高效液相色谱法 加替沙星 左氧氟沙星 奥硝唑 胆汁 胰液 |
| 文章编号： | 1001-2494（2006）06-0445-03 |
| 收稿时间： | 2005-04-23 |
| 修稿时间： | 2005-04-23 |
Determination of Gatifloxacin, Levofloxacin and Ornidazole in Bile and Pancreatic Juice by RP-HPLC |
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| REN Zhi-qiang,ZHANG Bi-kui,TONG Qi-wen,LIU Li-jun.Determination of Gatifloxacin, Levofloxacin and Ornidazole in Bile and Pancreatic Juice by RP-HPLC[J].Chinese Pharmaceutical Journal,2006,41(6):445-447. |
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| Authors: | REN Zhi-qiang ZHANG Bi-kui TONG Qi-wen LIU Li-jun |
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| Institution: | 1.Yiyang Central Hospital，Yiyang 413000，China；2.Second Xiangya Hospital of Central Southern University， Changsha 410011，China |
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| Abstract: | OBJECTIVE To establish a RP-HPLC method for the determination of gatifloxacin,levofloxacin and ornidazole in human bile and pancreatic juice.METHODS The mobile phase was acetonitrile-0.3% phosphoric acid(16∶84,pH 2.5 adjusted by triethylamine).The flow rate was 1.0 mL·min-1.The wavelength of UV detection was 286 nm. RESULTS The linearity was obtained in the rang of 0.064～4.80 mg·L-1 of gatifloxacin,0.064～4.80 mg·L-1 of levofloxacin and 0.16～12.80 mg·L-1 of ornidazole.The average recovery and relative standard deviation were good.CONCLUSION The established method can be used for the determination of the drugs mentioned in bile and pancreatic juice. |
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| Keywords: | RP-HPLC gatifloxacin levofloxacin ornidazole bile pancreatic juice |
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