Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission |
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Authors: | Raimondo Joseph V Kay Louise Ellender Tommas J Akerman Colin J |
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Affiliation: | Department of Pharmacology, Oxford University, Oxford, UK. |
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Abstract: | Optogenetic silencing using light-driven ion fluxes permits rapid and effective inhibition of neural activity. Using rodent hippocampal neurons, we found that silencing activity with a chloride pump can increase the probability of synaptically evoked spiking after photoactivation; this did not occur with a proton pump. This effect can be accounted for by changes to the GABA(A) receptor reversal potential and demonstrates an important difference between silencing strategies. |
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