热休克蛋白70和27在非小细胞肺癌中的表达和临床意义

目的研究热休克蛋白(heatshockprotein,HSP)70和27在非小细胞肺癌(nonsmallcelllungcancer,NSCLC)组织中的表达,探讨HSP70和HSP27与NSCLC细胞的组织学类型、分化和转移之间的关系。方法采用免疫组化SP法检测60例NSCLC标本中HSP70和HSP27的表达情况。结果NSCLC中HSP70和HSP27的表达与肿瘤细胞组织学类型无关。HSP70和HSP27的表达正相关。HSP70的表达与肿瘤细胞分化程度和淋巴结转移明显相关,HSP27的表达则无关。结论HSP70在NSCLC中的高表达与肿瘤细胞的分化和转移明显正相关,提示HSP70可以作为NSCLC辅助诊断和估计预后的指标。而HSP27尽管在多种恶性肿瘤中发挥促进细胞恶变的作用,但在NSCLC中的作用需要进一步研究。

Expression and clinical significance of HSP70 and HSP27 in non-small cell lung cancer

Objective To investigate the expression of HSP70 and HSP27 in non-small cell lung cancer (NSCLC) tissues,and the relationship between HSP70,HSP27 and histological types,histopathological differentiation and lymph node metastasis.Methods SP immunohistochemical technique was used to detect the expressions of HSP70 and HSP27 in NSCLC tissues.The results were analyzed in combination with the histological types,histopathological differentiation and lymph node metastasis of NSCLC.Results The expression of HSP70 and HSP27 was not correlated to the histologic types of NSCLC.The expression of HSP70 was significantly correlated to that of HSP27.Both the histopathological differentiation and metastasis were correlated to the expression of HSP70,however,not to the expression of HSP27.Conclusion The expression of HSP70 in NSCLC tissues was related to the differentiation and metastasis of cancer cells,and it could be used as a useful marker of a supplementary diagnosis and prognosis for patients with NSCLC.In contrast,the roles of HSP27 in NSCLC need to be further studied,although implicated in cellular processes potentially related to malignant transformation in many other human cancers.