| Institution: | 1. Department of Neuropsychiatry, Hanyang University Guri Hospital, Guri, Republic of Korea;2. Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea;3. Institute of Mental Health, Peking University, Beijing, China;4. Department of Psychiatry, Chinese University of Hong Kong, Hong Kong Special Administrative Region;5. Department of Neuropsychiatry, Kyushu University, Fukuoka, Japan;6. Chang Gung Memorial Hospital, Chiayi, and Chang Gung University School of Medicine, Taiwan;7. Department of Psychiatry, King George’s Medical University, Chowk, Lucknow, India;8. Department of Psychiatry, Faculty of Medicine, Prince of Songkhla University, Songkhla, Thailand;9. Tunku Abdul Rahman Institute of Neuroscience, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia;10. Wahidin Sudirohusodo University, Makassar, Sulawesi Selatan, Indonesia;11. National Institute of Mental Health, Dhaka, Bangladesh;12. Pakistan Psychiatric Research Centre, Fountain House, Lahore, Pakistan;13. Department of Psychiatry, University of Sri Jayewardenepura, Nugegoda, Sri Lanka;14. Department of Mental Health, University of Medicine (1), Yangon, Myanmar;15. National Psychiatry Hospital, Hanoi, Viet Nam;p. Institute of Mental Health, Singapore, Singapore;q. Deparment of Pharmacy, Songde Branch, Tapei City Hospital, Tapei, Taiwan;r. Association of the Improvement of Mental Health Programs, Geneva, Switzerland;s. Department of Pharmacology, National University Hospital, Singapore, Singapore;t. Department of Social Welfare, School of Human Sciences, Seinan Gakuin University, Fukuoka, Japan;u. Department of Psychiatry, Inje University College of Medicine and Haeundae Paik Hospital, Busan, Republic of Korea |
| Abstract: | BackgroundAlthough disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large samples of schizophrenia patients.ObjectiveWe aimed to examine the prevalence of disorganized speech and its correlates in terms of psychotropic drug prescribing, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study.MethodA total of 3744 patients with the ICD-10 diagnosis of schizophrenia were enrolled from 71 survey centers in 15 Asian countries/areas. An essential criterion of disorganized speech was that it was “severe enough to impair substantially effective communication” as defined in the DSM-5. A binary logistic model was fitted to identify the psychotropic drug-prescribing correlates of disorganized speech.ResultsAfter adjusting for the potential effects of confounding variables, the binary logistic regression model showed that the presence of disorganized speech was directly associated with adjunctive use of mood stabilizers (P?<?0.001) and cumulative diazepam equivalent dose (P?<?0.0001), and inversely associated with adjunctive use of anti-Parkinson drugs (P?<?0.0001).ConclusionThe association between disorganized speech and adjunctive use of mood stabilizers could perhaps be understood in the context of a relationship with impulsiveness/aggressiveness, or in terms of deconstructing the Kraepelinian dualism. |
