Individualized 3D-printed templates for high-dose-rate interstitial multicathether brachytherapy in patients with breast cancer |
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Authors: | Cynthia Aristei Valentina Lancellotta Marco Piergentini Giacomo Costantini Simonetta Saldi Sara Chierchini Antonella Cavalli Luca Di Renzo Oscar Fiorucci Massimo Guasticchi Vittorio Bini Alessandro Ricci |
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Affiliation: | 1. Radiation Oncology Section, Department of Surgical and Biomedical Science, University of Perugia and Perugia General Hospital, Italy;2. 3dific srl, Innovative Startup, University of Perugia, Italy;3. Radiation Oncology Section, Department of Haematology, Medical and Radiation Oncology and Gastroenterology, Perugia General Hospital, Italy;4. Radiation Oncology Section, Department of Surgical and Biomedical Science, University of Perugia, Italy;5. Degree Course (BSc) for Radiography Technicians, Department of Surgical and Biomedical Science, University of Perugia and Perugia General Hospital, Italy;6. Internal Medicine, Endocrine and Metabolic Science Section, Department of Medicine, University of Perugia, Italy |
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Abstract: | PurposeHigh-dose-rate, multicatheter interstitial brachytherapy is technically complex and operator-dependent, requiring lengthy training and specialized skills. Furthermore, until the advent of contouring on computerized tomography (CT) images, difficulties existed in locating the target volume precisely. The present article reports the results of a study that aimed at producing and validating a 3D-printed template to aid in target volume localization for multicatheter interstitial brachytherapy in patients with breast cancer.Methods and MaterialsThirteen patients, candidates for accelerated partial breast irradiation or boost, were enrolled in the study. The target volume was defined on CT slices, and a template with empty spaces corresponding to the target volume projection on the patient's skin was produced by a 3D printer. The procedure was compared with the standard method followed in our center (1) visually, by assessing overlap between the target volume projections on the patient's skin, (2) by X-ray findings, and (3) by intraclass correlation coefficient.ResultsVisual assessment and X-ray findings showed the 3D-printed target volume always fell within the standard volume in all 13 patients. The intraclass correlation coefficient indicated moderate agreement for both the medial and the lateral skin projections.ConclusionsThe 3-D printed templates constitute a quick, easy, and reliable method to localize the target volume for high-dose-rate interstitial multicathether brachytherapy in patients with breast cancer and can safely be used in clinical practice. |
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Keywords: | Breast cancer High-dose-rate interstitial multicathether brachytherapy 3D printing Three dimensional Breast template Target volume localization |
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