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Ovarian carcinogenesis: recent and past hypotheses |
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| Authors: | Chêne G Penault-Llorca F Raoelfils I Bignon Y-J Ray-Coquard I Seffert P Dauplat J |
| Affiliation: | a Département de chirurgie, centre Jean-Perrin, 58, rue Montalembert, 63011 Clermont-Ferrand, France b Département d’anatomopathologie, centre Jean-Perrin, 58, rue Montalembert, 63011 Clermont-Ferrand, France c Département d’oncologie moléculaire, centre Jean-Perrin, 58, rue Montalembert, 63011 Clermont-Ferrand, France d Département de gynécologie-obstétrique et médecine de la reproduction, CHU de Saint-Etienne, 42055 Saint-Étienne, France e Département d’oncologie médicale, centre Léon-Bérard, 28, rue Laennec, 69008 Lyon, France |
| Abstract: | Ovarian carcinogenesis and the early stages of malignant transformation are limited because of the lack of a candidate precursor. There have been several proposed hypotheses: first, ovary and the ovarian surface epithelium and more recently observations have increasingly focused attention of the Fallopian tube. Moreover, molecular genetic analysis has designed two main pathways of tumorogenesis. In this review, we discuss the different and perhaps complementary hypotheses about ovarian carcinogenesis. |
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