血栓通针剂联合西药常规治疗慢性心力衰竭随机平行对照研究

目的]观察血栓通针剂联合西药常规治疗慢性心力衰竭疗效。方法]使用随机平行对照方法,将90例住院患者按入院先后分为两组。对照组45例西药常规抗心衰,低盐饮食、吸氧、休息、利尿、抑制神经内分泌因子活性等。治疗组45例血栓通针剂300mg+5%葡萄糖250mL,1次/d,静滴;西药常规治疗同对照组。连续治疗14d为1疗程。观测临床症状、左心室射血分数、血浆NT-proBNP水平、不良反应。治疗1疗程,判定疗效。结果]治疗组痊愈10例,显效18例,有效14例,无效3例,总有效率93.33%。对照组痊愈8例,显效15例,有效16例,无效6例,总有效率86.67%。治疗组疗效优于对照组(P0.05)。左心室射血分数两组均有提高(P0.05),治疗组提高幅度大于对照组(P0.05)。血浆NT-proBNP水平两组均有下降(P0.05),治疗组下降幅度大于对照组(P0.05)。结论]血栓通针剂联合西药常规治疗慢性心力衰竭效果显著,值得推广。

Xueshuantong Injection Combined with Western Conventional Random Parallel Controlled Study of Chronic Heart Failure

Objective ] To observe the curative effect of conventional treatment of Xueshuantong injection combined with western medicine in chronic heart failure. Methods ] Using randomized controlled methods, 90 patients were divided into two groups according to admission. 45 cases of the control group routine anti heart failure therapy, low salt diet, smoking, rest, diuretic, inhibiting neuroendocrine factor activity etc.. The treatment group of 45 cases of Xueshuantong injection 300mg ＋ 5% Glucose Injection 250mL, 1 /d, intravenous drip of conventional western medicine treatment with the control group. Continuous treatment with 14d for 1 courses. Observation of clinical symptoms, left ventricular ejection fraction, the levels of plasma NT-proBNP, adverse reaction. 1 courses of treatment, the curative effect. Results ] The treatment group cured 10 cases, effective in 18 cases, effective 14 cases, invalid 3 cases, the total efficiency of 93.33%. The control group cured 8 cases, effective in 15 cases, effective 16 cases, invalid 6 cases, the total efficiency of 86.67%. The treatment group was better than control group （ P〈 0.05 ） . Left ventricular ejection fraction of two group were increased （ P〈 0.05 ）, the treatment group was greater than the control group （ P〈 0.05 ） . The plasma NT-proBNP levels of two groups were decreased （ P〈 0.05 ）, the treatment group decreased more than that in the control group （ P〈 0.05 ） . Conclusion ] Xueshuantong injection combined with western medicine conventional therapy in chronic heart failure effect is significant, worthy of promotion.