软肝汤联合阿德福韦酯治疗活动性肝硬化随机平行对照研究

目的]观察软肝汤联合阿德福韦酯治疗活动性肝硬化疗效。方法]使用随机平行对照方法,将80例门诊患者按随机数字表法分为两组。对照组40例阿德福韦酯,10mg/次,1次/d,口服。治疗组40例软肝汤(赤芍10g,太子参30g,丹参20g,莪术、虎杖各15g,何首乌10g,五味子20g,炙鳖甲、白花蛇舌草各30g),1剂/d,水煎500mL,早晚口服;阿德福韦酯治疗同对照组。连续治疗6个月为1疗程。观测临床症状、血清肝纤维化指标、不良反应。治疗1疗程,判定疗效。结果]治疗组显效5例,有效14例,无效21例,总有效率47.50%。对照组显效1例,有效4例,无效35例,总有效率12.50%。治疗组疗效优于对照组(P0.05)。血清肝纤维化指标(HA、LN、PCIII、IV-C)两组均有下降(P0.05),治疗组下降大于对照组(P0.05)。结论]软肝汤联合阿德福韦酯在治疗活动性肝硬化效果显著,值得推广。

Active Cirrhosis Randomized Parallel Group Study RuanganSoup Combined with Adefovir Dipivoxil

Objective ] Ruangan soup combined with adefovir dipivoxil treatment of active cirrhosis efficacy. Methods ] Random parallel control method, 80 outpatients were randomly divided into two groups. A control group of 40 patients with adefovir dipivoxil, 10mg / times, 1 times / d, orally. Treatment group, 40 cases of soft liver soup （red peony 10g, heterophylla 30g, Salvia 20g, Curcuma, Polygonum cuspidatum the 15g, Polygonum 10g, Schisandra 20g, Sunburn turtle, diffusa 30g ）, 1 does/d, decoction 500mL, sooner or later, oral ; adefovir dipivoxil treatment with the control group. Continuous treatment for 6 months for a course of treatment. Observation of clinical symptoms, serum liver fibrosis, adverse reactions. A course of treatment to determine efficacy. Results ] Treatment group five cases, effective in 14 cases, 21 cases, the total efficiency of 47.50%. Control group 1 cases markedly effective in 4 cases, 35 cases, the total efficiency of 12.50%. Treatment group than the control group （ P 〈0.05 ） . Serum liver fibrosis （ HA, LN, PCIII, IV-C ） decreased in both groups （ P 〈0.05 ）, the treatment group declined more than in the control group （ P 〈0.05 ） . Conclusion ] Ruangan soup joint adefovir in the treatment of active cirrhosis effect is significant, it is worth promoting.