疏肝和胃汤治疗反流性食管炎随机平行对照研究

[目的]观察疏肝和胃汤治疗反流性食管炎疗效。[方法]使用随机平行对照方法,将101例门诊患者按随机数字表法分为两组。对照组50例奥美拉唑,20mg/次,2次/d;硫糖铝,1g/次,3次/d;多潘立酮,10mg/次,3次/d。治疗组51例疏肝和胃汤(柴胡12g,白芍15g,枳壳12g,黄芩10g,姜半夏12g,陈皮、乌贼骨各10g,郁金12g,木香8g,甘草5g;情志不畅加元胡10g,柴胡加至15g,白芍加至18g;肝郁化热去郁金、木香,加大黄8g,瓜蒌18g,丹皮、栀子各6g;脾虚气滞去陈皮、枳壳、乌贼骨,加丁香3g,柿蒂18g,元胡10g;气虚血瘀加丹参、茯苓、元胡各10g),1剂/d,水煎100mL,3次/d。连续治疗30d为1疗程。观测临床症状、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈30例,显效15例,有效5例,无效1例,总有效率98.04%。对照组痊愈27例,显效11例,有效4例,无效8例,总有效率84.00%。治疗组疗效优于对照组(P0.05)。[结论]疏肝和胃汤治疗反流性食管炎效果显著,值得推广。

The Liver and Stomach Soup in Treatment of Reflux Esophagitis Random Parallel Control Study

[ Objective ] to observe the liver and stomach soup in treatment of reflux esophagitis curative effect. [ Methods ] using random parallel control method, 101 eases of clinic patients into two groups according to random number table method. The control group of 50 cases of omeprazole, 20 mg/times, 2 times/d;Sucralfate, 1 g/ time, 3 times/d;More Pan Li ketone, 10 mg/time, 3 times/d. Treatment group 51 eases of liver and stomach soup （Chaihu 12g, Bishao 15g, Zhike12g, Huangqi 10g, Jiangbanxia 12 g, Chenpi 10g, Wuzeigu 10 g, Yujin12g, MuxingSg, Gncao 5g;modem 10g, Chaihu add to 15g, Baisho add to 18g of heat to change to radix curcumae, radix aucklandiae, increase Yujin 8g, Muxiang 18g, Danpi, Zhizi every 6g;and to pixu （ spleen deficient ） dried tangerine orChenpi, Zhike, Wuzeigu, Dingxiang 3g, Shiti 18g, Yuanhu 10 g, hu qi difficiency and blood stasis and Danshen, Fuling, Yuanhu 10g ） . 1 / d, Fried 100 ml water, 3 times/d. Continuous treatment of 30 d for 1 course of treatment. Observation of clinical symptoms and adverse reactions. As a course treatment, judge curative effect. [ Results ] the treatment group 30 cases were cured, 15 cases were markedly improved, effective in 5 cases, and 1 had no effect, the total effective rate was 98.04%. Control group recovered 27 cases, 11 cases had marked effect, 4 cases were effective, 8 no effect, the total effective rate was 84.00%. The treatment group curative effect is better than that of control group （ P〈O.05 ） . [ Conclusion ] the liver and stomach soup in treatment of reflux esophagitis effect is remarkable, is worth promoting.