| 盐酸丁咯地尔对SD大鼠坐骨神经损害后神经元的保护作用 |
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| 引用本文： | 陈玉芳,苏建华,唐金荣,肖杭.盐酸丁咯地尔对SD大鼠坐骨神经损害后神经元的保护作用[J].蚌埠医学院学报,2006,31(6):582-583,F0003. |
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| 作者姓名： | 陈玉芳 苏建华 唐金荣 肖杭 |
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| 作者单位： | 江苏省常州市第四人民医院,病理科,213001;江苏省金坛市人民医院,神经内科,213200;南京医科大学第一附属医院,神经内科,江苏,南京210029;南京医科大学,应用神经毒理研究所,江苏,南京210029 |
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| 基金项目： | 江苏省常州市卫生局科研项目 |
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| 摘 要： | 目的:观察盐酸丁咯地尔对坐骨神经损害后神经元病理形态的改变.方法:以SD大鼠坐骨神经建立周围神经损害动物模型,观察背根神经节病理切片(光镜、电镜)中的神经元变化情况,考察盐酸丁咯地尔对坐骨神经损害后神经元的影响.结果:盐酸丁咯地尔给药4周后能显著地减轻背根神经节内神经元细胞坏死.结论:盐酸丁咯地尔对坐骨神经损害后神经元有确切的保护作用.
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| 关 键 词： | 创伤和损伤 坐骨神经 神经元 盐酸丁咯地尔 大鼠 |
| 文章编号： | 1000-2200（2006）06-0582-02 |
| 收稿时间： | 2005-12-26 |
| 修稿时间： | 2005-12-26 |
Protective effect of buflomdil hydrochloride on the neuron of damaged sciatic nerve in rats |
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| CHEN Yu-fang,SU Jian-hua,TANG Jin-rong,XIAO Hang.Protective effect of buflomdil hydrochloride on the neuron of damaged sciatic nerve in rats[J].Journal of Bengbu Medical College,2006,31(6):582-583,F0003. |
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| Authors: | CHEN Yu-fang SU Jian-hua TANG Jin-rong XIAO Hang |
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| Abstract: | Objective:To observe protective effect of buflomdil hydrochloride on the neuron of damaged sciatic nerve in rats.Methods:Sciatic nerve lesion model was established in rats,and the morphological changes of neuron cells of DRG treated with buflomedil hydrochloride were observed by light and electron microscope.Results:At the end of 4 weeks,buflomedil hydrochloride significantly decreased the damage of neuron of DRG.Conclusions:Buflomedic hydrochloride shows protective effect on neuron damaged sciatic nerve. |
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| Keywords: | wounds and injuries sciatic nerve neuron buflomedic hydrochloride rats |
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