全氟显声学显像效果的研究

目的：以Optison和5％声振人血白蛋白注射液为对照，评价新一代超声造影剂全氟显的声学显像效果。方法：全氟显设置低、中、高三个剂量组，Optison剂量设置与前者相同，5％声振人血白蛋白注射液仅设高剂量组。观察造影剂注射前后左室显影等级及内膜边界改善的效果，同时评价其对实验犬心,率、血压的影响。结果：全氟显左室显影等级强度、内膜边界增强节段数均高于5％声振人血白蛋白注射液，但与同剂量Optison组间无差异。三种造影剂对实验犬心率、血压未见明显影响。结论：全氟显经静脉注射后可实现左室腔显影增强，提高内膜边界识别。 该造影剂与Optison性能相似，优于5％声振人血白蛋白注射液。

Efficacy of a New Novel Left Heart Contrast Agent of Quanfuxian

Objective:To campare the efficacy of a new novel left heart contrast agent Quanfuxian (QFX),Optison and 5% sonicated human albumin in 6 dogs.Methods:Each dog received QFX (0 002,0 006 and 0 034 ml/kg),Optison (0 002,0 006 and 0 034 ml/kg)and 5% sonicated human albumin (0 034 ml/kg)in random order.Left heart opacification grades and numbers of endocardial border delineation segment were observed after each contrast injection.Heart rate and blood pressure were recorded before and after each injection.Results:Compared with 5% sonicatd human albumin,QFX and Optison more significantly improved every measure of contrast enhancement.There was no difference between OFX and Opitson in left heart opacification grades and augment segment numbers.All three agents had no side effect on heart rate and blood pressure of dogs.Conclusions:OFX appears to be a safe agent that is superior to 5% sonicated human albumin,and there is no difference bwtween QFX and Optison.